Update on the management of colchicine resistant Familial Mediterranean Fever (FMF).
Autoinflammatory diseases
Biologics
Colchicine resistance
Familial Mediterranean fever
Journal
Orphanet journal of rare diseases
ISSN: 1750-1172
Titre abrégé: Orphanet J Rare Dis
Pays: England
ID NLM: 101266602
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
08
06
2019
accepted:
13
09
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
1
7
2020
Statut:
epublish
Résumé
Familial Mediterranean Fever (FMF), an autoinflammatory disease, is characterized by self-limited inflammatory attacks of fever and polyserositis along with high acute phase response. Although colchicine remains the mainstay in treatment, intolerance and resistance in a certain portion of patients have been posing a problem for physicians. Like many autoimmune and autoinflammatory diseases, many colchicine-resistant or intolerant FMF cases have been successfully treated with biologics. In addition, many studies have tested the efficacy of biologics in treating FMF manifestations. Since carriers of FMF show significantly elevated levels of serum TNF alpha, IL-1, and IL-6, FMF patients who failed colchicine were successfully treated with anti IL-1, anti IL-6, or TNF inhibitors drugs. It is best to use colchicine in combination with biologics.
Sections du résumé
BACKGROUND
Familial Mediterranean Fever (FMF), an autoinflammatory disease, is characterized by self-limited inflammatory attacks of fever and polyserositis along with high acute phase response. Although colchicine remains the mainstay in treatment, intolerance and resistance in a certain portion of patients have been posing a problem for physicians.
MAIN BODY
Like many autoimmune and autoinflammatory diseases, many colchicine-resistant or intolerant FMF cases have been successfully treated with biologics. In addition, many studies have tested the efficacy of biologics in treating FMF manifestations.
CONCLUSION
Since carriers of FMF show significantly elevated levels of serum TNF alpha, IL-1, and IL-6, FMF patients who failed colchicine were successfully treated with anti IL-1, anti IL-6, or TNF inhibitors drugs. It is best to use colchicine in combination with biologics.
Identifiants
pubmed: 31615541
doi: 10.1186/s13023-019-1201-7
pii: 10.1186/s13023-019-1201-7
pmc: PMC6794843
doi:
Substances chimiques
Interleukin-1
0
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Colchicine
SML2Y3J35T
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
224Références
J Rheumatol. 1993 Sep;20(9):1544-9
pubmed: 8164212
Ann Rheum Dis. 2007 Nov;66(11):1545-6
pubmed: 17934085
Mod Rheumatol. 2015 Jul;25(4):621-4
pubmed: 25528863
Ann Rheum Dis. 2012 Oct;71(10):1599-605
pubmed: 22661645
Drug Des Devel Ther. 2015 Apr 17;9:1983-7
pubmed: 25945034
Rheumatol Int. 2018 Jan;38(1):67-74
pubmed: 28828621
Mod Rheumatol. 2016 Jul;26(4):610-3
pubmed: 25619282
Blood. 2000 May 15;95(10):3223-31
pubmed: 10807793
Neth J Med. 2008 Dec;66(11):489-91
pubmed: 19075317
Clin Rheumatol. 2017 Aug;36(8):1707-1713
pubmed: 28624931
Clin Rheumatol. 2006 Feb;25(1):83-7
pubmed: 16172948
QJM. 1997 Oct;90(10):643-7
pubmed: 9415347
Acta Reumatol Port. 2017 Jan-Mar;42(1):88-90
pubmed: 28371574
Am J Med. 1991 Apr;90(4):434-8
pubmed: 2012083
Nat Biotechnol. 2012 Sep;30(9):858-67
pubmed: 22902532
Rheumatol Int. 2015 Oct;35(10):1733-7
pubmed: 26001859
Intern Med. 2007;46(15):1247-9
pubmed: 17675778
Semin Arthritis Rheum. 2011 Oct;41(2):265-71
pubmed: 21277619
Ann Intern Med. 2007 Jun 5;146(11):825-6
pubmed: 17548423
Rheumatol Int. 2018 May;38(5):879-885
pubmed: 29450637
Intern Med. 2010;49(6):619-22
pubmed: 20228604
J Clin Rheumatol. 2011 Oct;17(7):358-62
pubmed: 21946459
N Engl J Med. 2018 May 17;378(20):1908-1919
pubmed: 29768139
Clin Rheumatol. 2019 Feb;38(2):577-581
pubmed: 30062447
Pediatrics. 2007 Feb;119(2):e474-83
pubmed: 17242135
Mod Rheumatol. 2016;26(3):458-9
pubmed: 24533541
Rev Med Interne. 2018 Apr;39(4):240-255
pubmed: 29526329
Nephron. 1992;60(4):418-22
pubmed: 1584316
J Rheumatol. 2016 Jan;43(1):154-60
pubmed: 26568587
Medicine (Baltimore). 2005 Jan;84(1):1-11
pubmed: 15643295
Arthritis Res Ther. 2015 Sep 04;17:243
pubmed: 26337145
J Rheumatol. 1999 Apr;26(4):890-7
pubmed: 10229412
Eur J Pediatr. 2008 Jun;167(6):695-6
pubmed: 17588171
Ann Rheum Dis. 2015 Apr;74(4):635-41
pubmed: 25628446
Rev Bras Reumatol Engl Ed. 2016 Jan-Feb;56(1):37-43
pubmed: 27267332
N Z Med J. 2007 Feb 16;120(1249):U2429
pubmed: 17308565
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9982-7
pubmed: 16785446
Mod Rheumatol. 2019 Mar;29(2):363-366
pubmed: 29578360
Transplantation. 2010 Jul 15;90(1):102-3
pubmed: 20606570
Clin Exp Med. 2005 Oct;5(3):87-98
pubmed: 16284730
Eur J Rheumatol. 2017 Mar;4(1):66-67
pubmed: 28293457
Am J Obstet Gynecol. 2010 Aug;203(2):144.e1-6
pubmed: 20579964
Mol Cell Pediatr. 2016 Dec;3(1):33
pubmed: 27590627
Front Immunol. 2017 Jan 27;8:43
pubmed: 28191008
J Clin Rheumatol. 2004 Jun;10(3):134-7
pubmed: 17043487
Ann Rheum Dis. 2014 Feb;73(2):455-61
pubmed: 23505238
Arthritis Rheumatol. 2014 Nov;66(11):3241-3
pubmed: 25049046
J Eur Acad Dermatol Venereol. 2013 Jul;27(7):912-5
pubmed: 22243424
Nephrol Dial Transplant. 2009 Feb;24(2):676-8
pubmed: 19033248
Scand J Rheumatol. 2017 Sep;46(5):407-409
pubmed: 28097903
Eur J Clin Invest. 2007 Nov;37(11):912-4
pubmed: 17973784
Blood. 1995 Jun 15;85(12):3586-93
pubmed: 7780142
Intern Med. 2019 Jun 15;58(12):1781-1785
pubmed: 30713308
Eur J Rheumatol. 2018 Dec;5(4):230-234
pubmed: 30501849
Fertil Steril. 1972 Mar;23(3):180-1
pubmed: 5058923
Ann Rheum Dis. 2011 Jul;70(7):1347-8
pubmed: 21345814
N Engl J Med. 2003 Jun 19;348(25):2583-4
pubmed: 12815153
Bratisl Lek Listy. 2018;119(4):198-200
pubmed: 29663815
Drugs Today (Barc). 2009 Jun;45(6):423-30
pubmed: 19649332
J Inflamm Res. 2016 Mar 17;9:13-20
pubmed: 27051312
Clin Rheumatol. 2016 Feb;35(2):441-6
pubmed: 25213327
Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77
pubmed: 24818516
Clin Rheumatol. 2003 May;22(2):99-101
pubmed: 12740672
J Rheumatol. 2005 May;32(5):859-62
pubmed: 15868622
Semin Arthritis Rheum. 2002 Jun;31(6):371-6
pubmed: 12077709
Clin Rheumatol. 2019 Apr;38(4):1125-1130
pubmed: 30535829
Rheumatology (Oxford). 2017 Sep 1;56(9):1627-1628
pubmed: 28486679
Clin Transplant. 2018 Aug;32(8):e13345
pubmed: 29981275
Arthritis Rheum. 2005 Feb 15;53(1):146-7
pubmed: 15696552
QJM. 1996 Mar;89(3):205-10
pubmed: 8731564
J Rheumatol. 2006 Jun;33(6):1089-92
pubmed: 16755655
Rheumatology (Oxford). 2014 Apr;53(4):741-5
pubmed: 24369413
N Z Med J. 2007 Jan 26;120(1248):U2402
pubmed: 17277818
Eur J Rheumatol. 2014 Mar;1(1):21-33
pubmed: 27708867
Clin Kidney J. 2014 Apr;7(2):219-20
pubmed: 25852877
Arthritis Rheumatol. 2017 Apr;69(4):854-862
pubmed: 27860460
Clin Immunol. 2019 Sep;206:23-32
pubmed: 30394352
Am J Med Genet A. 2004 Jan 1;124A(1):67-73
pubmed: 14679589
Clin Exp Rheumatol. 2013 May-Jun;31(3 Suppl 77):150-1
pubmed: 24064027
J Pak Med Assoc. 2017 Jun;67(6):945-947
pubmed: 28585601
Clin Exp Rheumatol. 2006 Jul-Aug;24(4):435-7
pubmed: 16956436
Lancet. 2006 Mar 25;367(9515):1016-24
pubmed: 16564365
Nature. 2004 Mar 11;428(6979):198-202
pubmed: 15014504
Rheumatology (Oxford). 2015 Mar;54(3):564-5
pubmed: 25504961
Pediatrics. 1994 Jan;93(1):137-50
pubmed: 8265310
J Cell Biochem. 2012 Nov;113(11):3536-46
pubmed: 22730186
Z Rheumatol. 2018 Mar;77(2):127-134
pubmed: 28752409
Rheumatology (Oxford). 2012 Jun;51(6):1041
pubmed: 22403182
Ann Intern Med. 2012 Oct 16;157(8):533-41
pubmed: 23070486
Nephrol Dial Transplant. 2012 May;27(5):1898-901
pubmed: 21931121
Rheumatol Int. 2012 Jun;32(6):1801-4
pubmed: 20352226
Arthritis Rheum. 1997 Oct;40(10):1879-85
pubmed: 9336425
Nefrologia. 2016;36(1):63-6
pubmed: 26409501
Clin Rev Allergy Immunol. 2013 Aug;45(1):117-30
pubmed: 23322405
Clin Rheumatol. 2010 Feb;29(2):209-10
pubmed: 19774408
Joint Bone Spine. 2013 Dec;80(6):645-9
pubmed: 23928237
Mod Rheumatol. 2011 Dec;21(6):684-90
pubmed: 21567247
Am J Med. 1967 Aug;43(2):227-53
pubmed: 5340644
J Clin Rheumatol. 2007 Feb;13(1):38-40
pubmed: 17278949
Clin Toxicol (Phila). 2010 Jun;48(5):407-14
pubmed: 20586571
N Engl J Med. 1974 Oct 31;291(18):934-7
pubmed: 4606353
Biomed Res Int. 2014;2014:854842
pubmed: 25147819
J Dig Dis. 2014 Feb;15(2):102-4
pubmed: 24734305
Arthritis Care Res (Hoboken). 2010 Feb;62(2):143-8
pubmed: 20191511
Inflammation. 2015 Feb;38(1):27-31
pubmed: 25139580
Arthritis Rheum. 2009 Oct 15;61(10):1447-53
pubmed: 19790133
Mod Rheumatol. 2017 Mar;27(2):350-355
pubmed: 27328763
Rheumatol Int. 2012 Apr;32(4):1095-7
pubmed: 21431291
Clin Exp Rheumatol. 1998 Nov-Dec;16(6):721-4
pubmed: 9844766
J Rheumatol. 2013 Dec;40(12):2083-7
pubmed: 24128782
Ann Rheum Dis. 2016 Apr;75(4):644-51
pubmed: 26802180
J Rheumatol. 2011 Mar;38(3):516-8
pubmed: 21159830
Joint Bone Spine. 2008 Jul;75(4):504-5
pubmed: 18541452
Cell. 1997 Aug 22;90(4):797-807
pubmed: 9288758
Rheumatol Int. 2012 Oct;32(10):3277-9
pubmed: 20386914
Int J Rheum Dis. 2017 Nov;20(11):1868-1871
pubmed: 26481326