Accelerated lung function decline in an aluminium manufacturing industry cohort exposed to PM
PM10-PM2.5-ultrafine
aluminium
epidemiology
respiratory
statistics
Journal
Occupational and environmental medicine
ISSN: 1470-7926
Titre abrégé: Occup Environ Med
Pays: England
ID NLM: 9422759
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
22
04
2019
revised:
04
09
2019
accepted:
25
09
2019
pubmed:
17
10
2019
medline:
10
3
2020
entrez:
17
10
2019
Statut:
ppublish
Résumé
Occupational dust exposure has been associated with accelerated lung function decline, which in turn is associated with overall morbidity and mortality. In the current study, we assess potential benefits on lung function of hypothetical interventions that would reduce occupational exposure to fine particulate matter (PM Analyses were performed in a cohort of 6485 hourly male workers in an aluminium manufacturing company in the USA, followed between 1996 and 2013. We used the parametric g-formula to assess lung function decline over time under hypothetical interventions while also addressing time-varying confounding by underlying health status, using a composite risk score based on health insurance claims. A counterfactual scenario envisioning a limit on exposure equivalent to the 10th percentile of the observed exposure distribution of 0.05 mg/m Our results indicate that occupational PM
Identifiants
pubmed: 31615860
pii: oemed-2019-105908
doi: 10.1136/oemed-2019-105908
pmc: PMC7771835
mid: NIHMS1655789
doi:
Substances chimiques
Dust
0
Particulate Matter
0
Aluminum
CPD4NFA903
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
888-894Subventions
Organisme : NIA NIH HHS
ID : R01 AG026291
Pays : United States
Organisme : NIOSH CDC HHS
ID : R01 OH009939
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: KH has received compensation as a member of the scientific advisory board for Alcoa, Inc. (Pittsburgh, Pennsylvania) and for consulting for Alcoa, Inc. in the past. MRC has received salary support from Alcoa, Inc. through contracts with Stanford University (Stanford, California).
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