Normal Aging and Its Role in Cancer Metastasis.
Journal
Cold Spring Harbor perspectives in medicine
ISSN: 2157-1422
Titre abrégé: Cold Spring Harb Perspect Med
Pays: United States
ID NLM: 101571139
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
pubmed:
17
10
2019
medline:
28
9
2021
entrez:
17
10
2019
Statut:
epublish
Résumé
Metastasis is the most common cause of death, with treatments failing to provide a durable response. Aging is a key prognostic factor in many cancers. Emerging data suggest that normal age-related changes in the tumor microenvironment can contribute to metastatic progression. These changes encompass secreted factors, biophysical changes, and changes in both stromal and immune cell populations. These data also highlight the importance of conducting studies in preclinical models of appropriate age. Ultimately, therapies may also need to be tailored to reflect patient age, as markers of metastatic disease differ in young and aged populations. In this review, we will discuss some of the changes that occur during aging that increase the metastatic capacity of tumor cells.
Identifiants
pubmed: 31615864
pii: cshperspect.a037341
doi: 10.1101/cshperspect.a037341
pmc: PMC7461764
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Informations de copyright
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.
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