Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma.

Arthritis, Juvenile Child Consensus Humans Methotrexate / therapeutic use Prospective Studies Scleroderma, Localized / drug therapy
CLINICAL TRIALS DISEASE ACTIVITY SCORE METHOTREXATE PEDIATRIC RHEUMATIC DISEASES SCLERODERMA

Journal

The Journal of rheumatology
ISSN: 0315-162X
Titre abrégé: J Rheumatol
Pays: Canada
ID NLM: 7501984

Informations de publication

Date de publication:
01 08 2020
Historique:
accepted: 30 09 2019
pubmed: 17 10 2019
medline: 1 9 2021
entrez: 17 10 2019
Statut: ppublish

Résumé

To perform a comparative effectiveness feasibility study in juvenile localized scleroderma (LS), using standardized treatment regimens (consensus treatment plans; CTP). A prospective, multicenter 1-year pilot observational cohort study was performed by Childhood Arthritis and Rheumatology Research Alliance (CARRA) LS workgroup members. Patients with active, moderate to severe juvenile LS were treated with one of 3 CTP: methotrexate alone, or in combination with intravenous (30 mg/kg/dose for 3 mos) or oral corticosteroids (2 mg/kg/day tapered by 48 weeks). Fifty patients, with demographics typical for juvenile LS, were enrolled, and 44 (88%) completed the study. Most had extracutaneous involvement. Patients improved in all 3 CTP, with > 75% having a major or moderate level of improvement compared to baseline. Damage accrued in some patients. Major deviations from prescribed regimen resulted from medication intolerance (n = 6; 14%) or treatment failure (n = 11; 25%); failures occurred in all 3 CTP. Significant responses to treatment were demonstrated by LS skin scoring measures and overall physician assessments, with differences in response level identified in some patient subsets. Response differences were associated with baseline disease activity level, LS subtype, skin disease extent, and extracutaneous involvement. This study demonstrates the feasibility of conducting juvenile LS comparative effectiveness studies. The CTP were found to be safe, effective, and tolerable. Our assessments performed well. Because damage is common and may progress despite effective control of activity, we recommend initial treatment efficacy be evaluated primarily by activity measures. Potential confounders for response were identified that warrant further study.

Identifiants

DOI: 10.3899/jrheum.190311 PMID: 31615917
pubmed: 31615917
pii: jrheum.190311
doi: 10.3899/jrheum.190311
doi:

Substances chimiques

Methotrexate YL5FZ2Y5U1

Types de publication

Journal Article Multicenter Study Observational Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1242-1252

Subventions

Organisme : NIAMS NIH HHS
ID : RC2 AR058934
Pays : United States

Auteurs

Suzanne C Li (SC)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada. suzanne.li@hackensackmeridian.org.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health. suzanne.li@hackensackmeridian.org.
ORCID: 0000-0001-8276-2866

Kathryn S Torok (KS)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.
ORCID: 0000-0002-1662-143X

C Egla Rabinovich (CE)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.

Fatma Dedeoglu (F)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.
ORCID: 0000-0002-7516-0848

Mara L Becker (ML)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.

Polly J Ferguson (PJ)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.
ORCID: 0000-0002-9901-0334

Sandy D Hong (SD)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.

Maria F Ibarra (MF)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.

Katie Stewart (K)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.

Elena Pope (E)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.
ORCID: 0000-0002-0911-9310

Gloria C Higgins (GC)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.

Ronald M Laxer (RM)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.

Thomas Mason (T)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.
ORCID: 0000-0002-7703-8002

Robert C Fuhlbrigge (RC)

From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Duke University School of Medicine, Durham, North Carolina; Boston Children's Hospital, Boston, Massachusetts; Children's Mercy Hospital, Kansas City, Missouri; University of Iowa Carver College of Medicine; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa; Children's Medical Center of Dallas and UT Southwestern, Dallas, Texas; The Ohio State University, Columbus, Ohio; Mayo Clinic, Rochester, Minnesota; University of Colorado-Denver and Children's Hospital Colorado, Denver, Colorado; Rutgers University, School of Public Health, Newark, New Jersey, USA; University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
S.C. Li, MD, PhD, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University; K.S. Torok, MD, UPMC Children's Hospital of Pittsburgh; C.E. Rabinovich, MD, MPH, Duke University School of Medicine; F. Dedeoglu, MD, Boston Children's Hospital; M.L. Becker, MD, MSCE, Children's Mercy Hospital; P.J. Ferguson, MD, University of Iowa Carver College of Medicine; S.D. Hong, MD, University of Iowa Stead Family Children's Hospital; M.F. Ibarra, MD, Children's Mercy Hospital; K. Stewart, MD, Children's Medical Center of Dallas and UT Southwestern; E. Pope, MD, University of Toronto and The Hospital for Sick Children; G.C. Higgins, MD, PhD, The Ohio State University; R.M. Laxer, MD, University of Toronto and The Hospital for Sick Children; T. Mason II, MD, Mayo Clinic; R.C. Fuhlbrigge, MD, PhD, University of Colorado-Denver, and Children's Hospital Colorado; T. Andrews, MA, Rutgers University, School of Public Health.
ORCID: 0000-0002-0911-9310

Tracy Andrews (T)

ORCID: 0000-0002-2926-390X

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Arthrite juvénile › Initial Results from a Pilot Comparative...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Initial Results from a Pilot Comparative...
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