Effects of Cognitive Performance and Affective Status on Fatigue in Parkinson's Disease.
Apathy
Cognition
Depression
Fatigue
Parkinson's disease
Sleepiness
Journal
Dementia and geriatric cognitive disorders extra
ISSN: 1664-5464
Titre abrégé: Dement Geriatr Cogn Dis Extra
Pays: Switzerland
ID NLM: 101564825
Informations de publication
Date de publication:
Historique:
received:
10
09
2018
accepted:
12
02
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
17
10
2019
Statut:
epublish
Résumé
Fatigue is a common non-motor symptom in Parkinson's disease (PD) and is typically assessed via self-reported questionnaires such as the Parkinson's Fatigue Scale (PFS). The PFS captures the presence of subjective experience of physical fatigue as well as its impact on daily functioning. We aimed to investigate whether different variables (cognition, neuropsychiatric symptoms, disease-related measures) are associated with the experience of physical fatigue in comparison to fatigue affecting daily functioning. Sixty-two non-demented PD patients were evaluated through questionnaires assessing fatigue, daytime sleepiness, apathy, depression, anxiety, and cognition. Items of fatigue were classified and summarized into two index variables measuring either the subjective experience of physical fatigue or the impact of fatigue on daily functioning. Linear regression with a stepwise elimination procedure was conducted to select the significant predictors for each index variable separately. Subjective experience of physical fatigue (Model 1; In conclusion, our work supports associations between fatigue and other neuropsychiatric symptoms in PD and extends prior work suggesting that motor disturbances are specifically linked to fatigue-related impairment of daily functioning, but not to the subjective experience of physical fatigue.
Sections du résumé
BACKGROUND
BACKGROUND
Fatigue is a common non-motor symptom in Parkinson's disease (PD) and is typically assessed via self-reported questionnaires such as the Parkinson's Fatigue Scale (PFS). The PFS captures the presence of subjective experience of physical fatigue as well as its impact on daily functioning.
OBJECTIVES
OBJECTIVE
We aimed to investigate whether different variables (cognition, neuropsychiatric symptoms, disease-related measures) are associated with the experience of physical fatigue in comparison to fatigue affecting daily functioning.
METHOD
METHODS
Sixty-two non-demented PD patients were evaluated through questionnaires assessing fatigue, daytime sleepiness, apathy, depression, anxiety, and cognition. Items of fatigue were classified and summarized into two index variables measuring either the subjective experience of physical fatigue or the impact of fatigue on daily functioning. Linear regression with a stepwise elimination procedure was conducted to select the significant predictors for each index variable separately.
RESULTS
RESULTS
Subjective experience of physical fatigue (Model 1;
CONCLUSIONS
CONCLUSIONS
In conclusion, our work supports associations between fatigue and other neuropsychiatric symptoms in PD and extends prior work suggesting that motor disturbances are specifically linked to fatigue-related impairment of daily functioning, but not to the subjective experience of physical fatigue.
Identifiants
pubmed: 31616458
doi: 10.1159/000498883
pii: dee-0009-0344
pmc: PMC6792463
doi:
Types de publication
Journal Article
Langues
eng
Pagination
344-351Informations de copyright
Copyright © 2019 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflict of interests to declare.
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