Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation.
aging
antidepressant
atherosclerosis
senescence
vascular cognitive impairment
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
02
2019
accepted:
23
08
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
17
10
2019
Statut:
epublish
Résumé
Late life depression is an important public health problem, which associates with increased risk of morbidity and mortality. Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, are often prescribed to treat geriatric depression. There is increasing evidence that fluoxetine and other SSRIs exert a wide range of cardiovascular side effects. Furthermore, there is evidence that aging may increase plasma level of SSRIs. In this overview, the potential role of side effects of treatment with fluoxetine and other SSRIs in the pathogenesis of age-related cardiovascular diseases, including atherogenesis, cardiac pathologies, and cerebromicrovascular impairment, is discussed.
Identifiants
pubmed: 31616477
doi: 10.3389/fgene.2019.00898
pmc: PMC6764114
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
898Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125528
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104938
Pays : United States
Informations de copyright
Copyright © 2019 Ungvari, Tarantini, Yabluchanskiy and Csiszar.
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