Crocetin protects against fulminant hepatic failure induced by lipopolysaccharide/D-galactosamine by decreasing apoptosis, inflammation and oxidative stress in a rat model.
apoptosis
crocetin
fulminant hepatic failure
inflammation
lipopolysaccharide/D-galactosamine
Journal
Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
09
10
2018
accepted:
05
07
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
17
10
2019
Statut:
ppublish
Résumé
Fulminant hepatic failure (FHF) is a clinical syndrome characterized by sudden and severe liver dysfunction. Apoptosis and inflammation are essential for the pathogenesis of FHF. Crocetin, the major component present in saffron, has been reported to possess anti-inflammatory and antioxidant functions; however, its role in FHF is poorly understood. The aim of this study was to explore the protective effects of crocetin against lipopolysac§§charide (LPS)/D-galactosamine (D-GalN)-induced FHF and the underlying mechanisms in a rat model. For the
Identifiants
pubmed: 31616509
doi: 10.3892/etm.2019.8030
pii: ETM-0-0-8030
pmc: PMC6781807
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3775-3782Informations de copyright
Copyright: © Gao et al.
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