Emtricitabine-induced pure red cell aplasia.
adverse drug reaction
antiretroviral
drug induced
emtricitabine
pure red cell aplasia
rare drug toxicity
Journal
Southern African journal of HIV medicine
ISSN: 2078-6751
Titre abrégé: South Afr J HIV Med
Pays: South Africa
ID NLM: 100965417
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
05
2019
accepted:
10
06
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
17
10
2019
Statut:
epublish
Résumé
Anemia is common in HIV. Parvo B19 infection is a well-recognised cause of red cell aplasia. Other causes of persistent pure red cell aplasia (PRCA) include anti-retroviral drugs such as zidovudine and lamivudine. We describe a case of PRCA that strongly implicates emtricitabine as the probable cause. Patient was HIV positive and on treatment with a fixed drug combination consisting of tenofovir, emtricitabine and efavirenz for 3 months when she developed severe transfusion dependent anemia. The anemia, attributed to PRCA, was persistent and transfusion dependent for about one year. Replacement of emtricitabine with abacavir resulted in a prompt, complete and lasting resolution of the anaemia, suggesting an etiologic role of emtricitabine in the PRCA. Emtricitibine is a rare cause of pure red cell aplasia.
Identifiants
pubmed: 31616574
doi: 10.4102/sajhivmed.v20i1.983
pii: HIVMED-20-983
pmc: PMC6779991
doi:
Types de publication
Case Reports
Langues
eng
Pagination
983Informations de copyright
© 2019. The Authors.
Déclaration de conflit d'intérêts
The authors have no conflict of interests.
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