HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly.
CD4-Positive T-Lymphocytes
/ immunology
Cell Survival
Cholesterol
/ metabolism
Diffusion
HIV-1
/ physiology
Humans
Jurkat Cells
Nanoparticles
/ chemistry
Phosphatidylinositol 4,5-Diphosphate
/ metabolism
Sphingomyelins
/ metabolism
Virion
/ metabolism
Virus Assembly
gag Gene Products, Human Immunodeficiency Virus
/ metabolism
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
31
01
2019
accepted:
09
09
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
22
5
2020
Statut:
epublish
Résumé
HIV-1 Gag protein assembles at the plasma membrane of infected cells for viral particle formation. Gag targets lipids, mainly PI(4,5)P2, at the inner leaflet of this membrane. Here, we address the question whether Gag is able to trap specifically PI(4,5)P2 or other lipids during HIV-1 assembly in the host CD4
Identifiants
pubmed: 31616784
doi: 10.1126/sciadv.aaw8651
pii: aaw8651
pmc: PMC6774721
doi:
Substances chimiques
Phosphatidylinositol 4,5-Diphosphate
0
Sphingomyelins
0
gag Gene Products, Human Immunodeficiency Virus
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaaw8651Subventions
Organisme : Medical Research Council
ID : MC_UU_00008/9
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12010/9
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM064347
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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