Conservation of Atypical Allostery in
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
08 Oct 2019
08 Oct 2019
Historique:
received:
28
05
2019
accepted:
06
09
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
17
10
2019
Statut:
epublish
Résumé
Human UDP-glucose dehydrogenase (hUGDH) oxidizes uridine diphosphate (UDP)-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of drugs. The activity of hUGDH is controlled by an atypical allosteric mechanism in which the feedback inhibitor UDP-xylose competes with the substrate for the active site and triggers a buried allosteric switch to produce an inactive complex (E
Identifiants
pubmed: 31616809
doi: 10.1021/acsomega.9b01565
pmc: PMC6788056
doi:
Types de publication
Journal Article
Langues
eng
Pagination
16318-16329Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114298
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114409
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM107004
Pays : United States
Informations de copyright
Copyright © 2019 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Science. 2012 May 25;336(6084):1030-3
pubmed: 22628654
J Comput Biol. 2016 Jan;23(1):21-6
pubmed: 26540459
Biochem Pharmacol. 2002 Feb 15;63(4):607-13
pubmed: 11992628
Biochem Biophys Res Commun. 1965 May 3;19:456-61
pubmed: 14338992
Biophys J. 2000 Mar;78(3):1606-19
pubmed: 10692345
Biochemistry. 2013 Feb 26;52(8):1456-65
pubmed: 23363239
Biochemistry. 2012 Nov 20;51(46):9364-74
pubmed: 23106432
J Biol Chem. 2004 Aug 6;279(32):33281-9
pubmed: 15190064
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Cancer Res. 2003 Dec 1;63(23):8443-50
pubmed: 14679008
Biophys J. 2011 Aug 17;101(4):892-8
pubmed: 21843480
Nature. 2018 Nov;563(7732):584-588
pubmed: 30420606
J Biol Chem. 1970 Nov 10;245(21):5788-99
pubmed: 5472372
Biochemistry. 2014 Dec 30;53(51):8043-51
pubmed: 25478983
Anticancer Res. 2004 Sep-Oct;24(5A):2893-6
pubmed: 15517893
Pharmacol Rev. 1997 Dec;49(4):403-49
pubmed: 9443165
Biochemistry. 2018 Dec 18;57(50):6848-6859
pubmed: 30457329
Biochemistry. 2011 Nov 8;50(44):9651-63
pubmed: 21961565
BMC Evol Biol. 2006 Mar 21;6:27
pubmed: 16551352
J Mol Biol. 1999 May 7;288(3):427-39
pubmed: 10329152
J Mol Biol. 2007 Sep 21;372(3):774-97
pubmed: 17681537
Methods. 2011 May;54(1):16-30
pubmed: 21315155
Proteins. 1998 Feb 1;30(2):144-54
pubmed: 9489922
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Nat Struct Biol. 1997 Apr;4(4):269-75
pubmed: 9095194
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Methods Enzymol. 1997;277:366-96
pubmed: 18488318
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
Cancer Res. 2009 Mar 15;69(6):2332-9
pubmed: 19244115
Annu Rev Pharmacol Toxicol. 2000;40:581-616
pubmed: 10836148
Pharmacogenomics J. 2003;3(3):136-58
pubmed: 12815363
Crystallogr Rev. 2013 Jul 1;19(4):230-270
pubmed: 25249713
PLoS One. 2010 Mar 10;5(3):e9490
pubmed: 20224823
Biochemistry. 2017 Jan 10;56(1):202-211
pubmed: 27966912
Trends Ecol Evol. 2001 Jul 1;16(7):358-364
pubmed: 11403868
J Chem Inf Model. 2011 Oct 24;51(10):2778-86
pubmed: 21919503
Biochem Pharmacol. 2011 Jan 1;81(1):60-70
pubmed: 20854796
Biochem J. 1975 Feb;145(2):129-34
pubmed: 239676
Biochemistry. 2011 Jun 28;50(25):5780-9
pubmed: 21595445
Exp Cell Res. 2009 Jul 1;315(11):1914-23
pubmed: 19285976
Anal Biochem. 2003 Sep 1;320(1):104-24
pubmed: 12895474