Nrf2-modulation by seleno-hormetic agents and its potential for radiation protection.
Nrf2
free radicals
glutathione
glutathione S-transferase
ionizing radiations
oxidant stress
selenium
seleno-hormesis
Journal
BioFactors (Oxford, England)
ISSN: 1872-8081
Titre abrégé: Biofactors
Pays: Netherlands
ID NLM: 8807441
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
16
08
2019
accepted:
25
09
2019
pubmed:
17
10
2019
medline:
9
1
2021
entrez:
17
10
2019
Statut:
ppublish
Résumé
The trace element selenium (Se) is an essential component of selenoproteins and plays a critical role in redox signaling via regulating the activity of selenoenzymes such as thioredoxin reductase-1 and glutathione peroxidases. Se compounds and its metabolites possess a wide range of biological functions including anticancer and cytoprotection effects, modulation of hormetic genes and antioxidant enzyme activities. Radiation-induced injury of normal tissues is a significant side effect for cancer patients who receive radiotherapy in the clinic and the development of new and effective radioprotectors is an important goal of research. Others and we have shown that seleno-compounds have the potential to protect ionizing radiation-induced toxicities in various tissues and cells both in in vitro and in vivo studies. In this review, we discuss the potential utilization of Se compounds with redox-dependent hormetic activity as novel radio-protective agents to alleviate radiation toxicity. The cellular and molecular mechanisms underlying the radioprotection effects of these seleno-hormetic agents are also discussed. These include Nrf2 transcription factor modulation and the consequent upregulation of the adaptive stress response to IR in bone marrow stem cells and hematopoietic precursors.
Substances chimiques
NF-E2 Transcription Factor
0
Radiation-Protective Agents
0
Selenoproteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-245Subventions
Organisme : European Agricultural Fund for Rural Development (EAFRD)
Organisme : Programma di Sviluppo Rurale (PSR)
Organisme : University of Perugia
Informations de copyright
© 2019 International Union of Biochemistry and Molecular Biology.
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