New Clones on the Block.

Clone Cells Humans Neoplasms Programmed Cell Death 1 Receptor T-Lymphocytes

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
15 10 2019
Historique:
entrez: 17 10 2019
pubmed: 17 10 2019
medline: 24 12 2019
Statut: ppublish

Résumé

Although immune checkpoint blockade (ICB) has yielded striking clinical responses in subsets of cancer patients, the mechanism of action is still unclear. In a recent issue of Nature Medicine, Yost et al., 2019 report that the T cell clones that dominate the intra-tumoral T cell landscape after ICB are distinct from those prior to treatment, a phenomenon referred to by the authors as "clonal replacement."

Identifiants

DOI: 10.1016/j.immuni.2019.09.018 PMID: 31618653
pubmed: 31618653
pii: S1074-7613(19)30414-5
doi: 10.1016/j.immuni.2019.09.018
pii:
doi:

Substances chimiques

Programmed Cell Death 1 Receptor 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

606-608

Subventions

Organisme : NIAID NIH HHS
ID : P01 AI073748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA229400
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA187975
Pays : United States

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Nandini Acharya (N)

Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

Ana C Anderson (AC)

Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: acanderson@bwh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Clones cellulaires › New Clones on the Block.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New Clones on the Block.
questionsmedicales.fr › Tumeurs › New Clones on the Block.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › New Clones on the Block.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › New Clones on the Block.