Investigating imaging network markers of cognitive dysfunction and pharmacoresistance in newly diagnosed epilepsy: a protocol for an observational cohort study in the UK.
brain connectivity
epilepsy
inflammation
neuropsychology
newly diagnosed
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
16 10 2019
16 10 2019
Historique:
entrez:
18
10
2019
pubmed:
18
10
2019
medline:
24
10
2020
Statut:
epublish
Résumé
Epilepsy is one of the most common serious brain disorders, characterised by seizures that severely affect a person's quality of life and, frequently, their cognitive and mental health. Although most existing work has examined chronic epilepsy, newly diagnosed patients present a unique opportunity to understand the underlying biology of epilepsy and predict effective treatment pathways. The objective of this prospective cohort study is to examine whether cognitive dysfunction is associated with measurable brain architectural and connectivity impairments at diagnosis and whether the outcome of antiepileptic drug treatment can be predicted using these measures. 107 patients with newly diagnosed focal epilepsy from two National Health Service Trusts and 48 healthy controls (aged 16-65 years) will be recruited over a period of 30 months. Baseline assessments will include neuropsychological evaluation, structural and functional Magnetic Resonance Imaging (MRI), Electroencephalography (EEG), and a blood and saliva sample. Patients will be followed up every 6 months for a 24-month period to assess treatment outcomes. Connectivity- and network-based analyses of EEG and MRI data will be carried out and examined in relation to neuropsychological evaluation and patient treatment outcomes. Patient outcomes will also be investigated with respect to analysis of molecular isoforms of high mobility group box-1 from blood and saliva samples. This study was approved by the North West, Liverpool East Research Ethics Committee (19/NW/0384) through the Integrated Research Application System (Project ID 260623). Health Research Authority (HRA) approval was provided on 22 August 2019. The project is sponsored by the UoL (UoL001449) and funded by a UK Medical Research Council (MRC) research grant (MR/S00355X/1). Findings will be presented at national and international meetings and conferences and published in peer-reviewed journals. IRAS Project ID 260623.
Identifiants
pubmed: 31619436
pii: bmjopen-2019-034347
doi: 10.1136/bmjopen-2019-034347
pmc: PMC6797398
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e034347Subventions
Organisme : Medical Research Council
ID : MR/L010909/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00355X/1
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Epilepsia. 2013 May;54 Suppl 2:5-8
pubmed: 23646962
Neuroimage. 2015 Sep;118:219-30
pubmed: 26054876
Ann Neurol. 2015 May;77(5):760-74
pubmed: 25627477
PLoS Comput Biol. 2015 Dec 10;11(12):e1004642
pubmed: 26657566
J Neurol Neurosurg Psychiatry. 2016 Sep;87(9):930-6
pubmed: 27076491
Brain. 2017 Jan;140(1):68-82
pubmed: 28031219
Stat Med. 2017 Oct 30;36(24):3858-3874
pubmed: 28762546
Epilepsia. 2014 Oct;55(10):1642-50
pubmed: 25169800
Neuroimage Clin. 2017 Jan 05;14:67-76
pubmed: 28138428
Epilepsia. 2011 Jun;52(6):1084-91
pubmed: 21453356
Neurology. 2015 May 5;84(18):1846-53
pubmed: 25854868
J Neurol Neurosurg Psychiatry. 2012 Dec;83(12):1238-48
pubmed: 22917671
Cereb Cortex. 2015 Nov;25(11):4477-89
pubmed: 25899706
Neurology. 2013 Nov 5;81(19):1704-10
pubmed: 24107863
Epilepsia. 2012 Sep;53(9):e166-9
pubmed: 22709380
Nat Med. 2010 Apr;16(4):413-9
pubmed: 20348922
Neuroimage. 2011 Feb 1;54(3):2020-32
pubmed: 20884353
Epilepsy Behav. 2015 Sep;50:162-70
pubmed: 26159729
Neurology. 2006 Mar 28;66(6 Suppl 3):S5-12
pubmed: 16567744
Neuroimage. 2010 Dec;53(4):1197-207
pubmed: 20600983
Neurology. 1997 Sep;49(3):753-7
pubmed: 9305336
Epilepsia. 2010 Jan;51(1):48-56
pubmed: 19583779
Epilepsy Curr. 2016 May-Jun;16(3):179-81
pubmed: 27330449
Epilepsia. 2002;43 Suppl 6:26-30
pubmed: 12190975
Epilepsia. 1998 Jun;39(6):633-9
pubmed: 9637606
Neurology. 2011 Sep 27;77(13):1305-7
pubmed: 21947534
Sci Rep. 2016 Mar 22;6:23153
pubmed: 27001417
Brain. 2017 Oct 1;140(10):2639-2652
pubmed: 28969369
Epilepsia. 2009 Mar;50(3):579-82
pubmed: 19317887
Hum Brain Mapp. 2009 Oct;30(10):3351-60
pubmed: 19347875
Seizure. 2013 Jun;22(5):333-44
pubmed: 23583115
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Epilepsy Behav. 2014 Jun;35:59-63
pubmed: 24798411
BMJ Open. 2017 Jul 10;7(7):e015868
pubmed: 28698335
Brain Behav. 2019 Jan;9(1):e01168
pubmed: 30488645
Epilepsia. 2013 May;54 Suppl 2:75-9
pubmed: 23646977
Mov Disord. 2013 Dec;28(14):1972-9
pubmed: 24123267
Antioxid Redox Signal. 2014 Oct 20;21(12):1726-40
pubmed: 24094148
J Neurol. 2017 Jun;264(6):1174-1184
pubmed: 28550480
Epilepsy Res. 2001 Mar;43(3):227-37
pubmed: 11248534
Epilepsia. 2011 May;52(5):965-74
pubmed: 21320116
Cogn Neurodyn. 2008 Jun;2(2):121-36
pubmed: 19003479
Neuroimage. 2005 Mar;25(1):294-311
pubmed: 15734364
Lancet. 2007 Mar 24;369(9566):1016-26
pubmed: 17382828
Brain. 2013 Jun;136(Pt 6):1868-88
pubmed: 23674488
Curr Opin Neurol. 2012 Apr;25(2):201-7
pubmed: 22274774
Front Psychol. 2017 Apr 12;8:557
pubmed: 28446889
Epilepsia. 2016 Oct;57(10):e200-e204
pubmed: 27501083