A regimen containing bedaquiline and delamanid compared to bedaquiline in patients with drug-resistant tuberculosis.

Antitubercular Agents / therapeutic use Diarylquinolines / therapeutic use Humans Nitroimidazoles Oxazoles Prospective Studies Tuberculosis, Multidrug-Resistant / drug therapy

Journal

The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460

Informations de publication

Date de publication:
01 2020
Historique:
received: 16 06 2019
accepted: 09 10 2019
pubmed: 18 10 2019
medline: 22 6 2021
entrez: 18 10 2019
Statut: epublish

Résumé

There are limited data on combining delamanid and bedaquiline in drug-resistant tuberculosis (DR-TB) regimens. Prospective long-term outcome data, including in HIV-infected persons, are unavailable.We prospectively followed up 122 South African patients (52.5% HIV-infected) with DR-TB and poor prognostic features between 2014 and 2018. We examined outcomes and safety in those who received a bedaquiline-based regimen (n=82) compared to those who received a bedaquiline-delamanid combination regimen (n=40).There was no significant difference in 6-month culture conversion (92.5%

Identifiants

DOI: 10.1183/13993003.01181-2019 PMID: 31619478
pubmed: 31619478
pii: 13993003.01181-2019
doi: 10.1183/13993003.01181-2019
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Diarylquinolines 0
Nitroimidazoles 0
OPC-67683 0
Oxazoles 0
bedaquiline 78846I289Y

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright ©ERS 2020.

Déclaration de conflit d'intérêts

Conflict of interest: O. Olayanju has no conflict of interest to declare. Conflict of interest: A. Esmail has no conflict of interest to declare. Conflict of interest: J. Limberis has no conflict of interest to declare. Conflict of interest: K. Dheda has no conflict of interest to declare.

Auteurs

Olatunde Olayanju (O)

Centre for Lung Infection and Immunity, Division of Pulmonology, Dept of Medicine, and UCT Lung Institute and South African MRC/UCT Centre for the Study of Antimicrobial Resistance, Division of Pulmonology, University of Cape Town, Cape Town, South Africa.
Co-first author.

Aliasgar Esmail (A)

Centre for Lung Infection and Immunity, Division of Pulmonology, Dept of Medicine, and UCT Lung Institute and South African MRC/UCT Centre for the Study of Antimicrobial Resistance, Division of Pulmonology, University of Cape Town, Cape Town, South Africa.
Co-first author.

Jason Limberis (J)

Centre for Lung Infection and Immunity, Division of Pulmonology, Dept of Medicine, and UCT Lung Institute and South African MRC/UCT Centre for the Study of Antimicrobial Resistance, Division of Pulmonology, University of Cape Town, Cape Town, South Africa.

Keertan Dheda (K)

Centre for Lung Infection and Immunity, Division of Pulmonology, Dept of Medicine, and UCT Lung Institute and South African MRC/UCT Centre for the Study of Antimicrobial Resistance, Division of Pulmonology, University of Cape Town, Cape Town, South Africa keertan.dheda@uct.ac.za.
Faculty of Infectious and Tropical Diseases, Dept of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › A regimen containing bedaquiline and delamanid...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Diarylquinoléines › A regimen containing bedaquiline and delamanid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A regimen containing bedaquiline and delamanid...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Nitroimidazoles › A regimen containing bedaquiline and delamanid...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › A regimen containing bedaquiline and delamanid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › A regimen containing bedaquiline and delamanid...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Tuberculose multirésistante › A regimen containing bedaquiline and delamanid...