Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease.
energy
mitochondria
neurodegenerative disease
neuronal development
synaptic function
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
16 10 2019
16 10 2019
Historique:
received:
02
07
2019
revised:
09
08
2019
accepted:
10
08
2019
entrez:
18
10
2019
pubmed:
18
10
2019
medline:
4
7
2020
Statut:
ppublish
Résumé
Mitochondria play many important biological roles, including ATP production, lipid biogenesis, ROS regulation, and calcium clearance. In neurons, the mitochondrion is an essential organelle for metabolism and calcium homeostasis. Moreover, mitochondria are extremely dynamic and able to divide, fuse, and move along microtubule tracks to ensure their distribution to the neuronal periphery. Mitochondrial dysfunction and altered mitochondrial dynamics are observed in a wide range of conditions, from impaired neuronal development to various neurodegenerative diseases. Novel imaging techniques and genetic tools provide unprecedented access to the physiological roles of mitochondria by visualizing mitochondrial trafficking, morphological dynamics, ATP generation, and ultrastructure. Recent studies using these new techniques have unveiled the influence of mitochondria on axon branching, synaptic function, calcium regulation with the ER, glial cell function, neurogenesis, and neuronal repair. This review provides an overview of the crucial roles played by mitochondria in the CNS in physiological and pathophysiological conditions.
Identifiants
pubmed: 31619488
pii: 39/42/8200
doi: 10.1523/JNEUROSCI.1157-19.2019
pmc: PMC6794931
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8200-8208Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103636
Pays : United States
Informations de copyright
Copyright © 2019 the authors.
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