Imbalance in the response of pre- and post-synaptic components to amyloidopathy.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 10 2019
16 10 2019
Historique:
received:
10
05
2019
accepted:
12
09
2019
entrez:
18
10
2019
pubmed:
18
10
2019
medline:
12
11
2020
Statut:
epublish
Résumé
Alzheimer's disease (AD)-associated synaptic dysfunction drives the progression of pathology from its earliest stages. Amyloid β (Aβ) species, both soluble and in plaque deposits, have been causally related to the progressive, structural and functional impairments observed in AD. It is, however, still unclear how Aβ plaques develop over time and how they progressively affect local synapse density and turnover. Here we observed, in a mouse model of AD, that Aβ plaques grow faster in the earlier stages of the disease and if their initial area is >500 µm
Identifiants
pubmed: 31619689
doi: 10.1038/s41598-019-50781-1
pii: 10.1038/s41598-019-50781-1
pmc: PMC6795896
doi:
Substances chimiques
APP protein, human
0
Amyloid beta-Peptides
0
Amyloid beta-Protein Precursor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14837Subventions
Organisme : Medical Research Council
ID : G1100623
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14127
Pays : United Kingdom
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