Observation after surgery for low grade glioma: long-term outcome in the light of the 2016 WHO classification.
1p19q co-deletion
IDH mutation
Low grade glioma
Observation
Journal
Journal of neuro-oncology
ISSN: 1573-7373
Titre abrégé: J Neurooncol
Pays: United States
ID NLM: 8309335
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
17
09
2019
accepted:
10
10
2019
revised:
08
10
2019
pubmed:
18
10
2019
medline:
18
4
2020
entrez:
18
10
2019
Statut:
ppublish
Résumé
To provide detailed long-term data after initial observation for patients after histological confirmation of low grade (WHO II) gliomas according to molecular stratification. A series of 110 patients with watchful waiting strategy after initial surgery for LGG and re-surgery at tumor progression were analyzed. Progression-free survival, time to malignant transformation, post-recurrence survival, and overall survival were estimated with the Kaplan-Meier method. Prognostic factors were identified by the Log Rank test and Cox multivariate proportional hazards model. The cohort comprised 18 IDH wild type (IDH The strongest determinant of the patients' course after initial watchful waiting was the molecular tumor status. Extensive resection may increase time to progression and malignant transformation. Observation may be justified in selected patients.
Identifiants
pubmed: 31621043
doi: 10.1007/s11060-019-03316-7
pii: 10.1007/s11060-019-03316-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
501-507Références
Clin Neurol Neurosurg. 2012 Oct;114(8):1135-44
pubmed: 22425370
J Neurooncol. 2016 Dec;130(3):529-533
pubmed: 27704386
N Engl J Med. 2016 Apr 7;374(14):1344-55
pubmed: 27050206
Clin Neurol Neurosurg. 2011 Nov;113(9):752-7
pubmed: 21889256
J Neurosurg. 2008 Nov;109(5):835-41
pubmed: 18976072
Neurosurgery. 2016 Jun;78(6):775-86
pubmed: 26516822
J Neurooncol. 2017 Dec;135(3):535-543
pubmed: 28836106
J Clin Oncol. 2013 Jan 20;31(3):337-43
pubmed: 23071247
Lancet. 2005 Sep 17-23;366(9490):985-90
pubmed: 16168780
Neurology. 2007 Sep 25;69(13):1366-73
pubmed: 17893297
J Neurosurg. 2003 Jun;98(6):1165-9
pubmed: 12816258
Lancet Oncol. 2016 Nov;17(11):1521-1532
pubmed: 27686946
J Clin Oncol. 1997 Apr;15(4):1294-301
pubmed: 9193320
Neuro Oncol. 2017 Oct 1;19(10):1327-1337
pubmed: 28575485
Cancer. 2006 Mar 15;106(6):1372-81
pubmed: 16470609
Int J Radiat Oncol Biol Phys. 2018 Mar 15;100(4):965-971
pubmed: 29485076
J Clin Oncol. 2012 Sep 1;30(25):3065-70
pubmed: 22851558
J Clin Oncol. 2008 Mar 10;26(8):1338-45
pubmed: 18323558
J Neurosurg. 2013 Jun;118(6):1157-68
pubmed: 23495881
Lancet Oncol. 2017 Jun;18(6):e315-e329
pubmed: 28483413
Neurosurgery. 2008 Apr;62(4):753-64; discussion 264-6
pubmed: 18496181
Cancer Res. 2006 Apr 15;66(8):3987-91
pubmed: 16618716
J Neurosurg. 2011 Nov;115(5):948-65
pubmed: 22043865
Eur J Neurol. 2010 Sep;17(9):1124-33
pubmed: 20718851
J Neurosurg. 2010 Jan;112(1):10-7
pubmed: 19361270
JAMA. 2012 Nov 14;308(18):1881-8
pubmed: 23099483
Acta Neuropathol. 2015 May;129(5):679-93
pubmed: 25783747
Acta Neuropathol. 2016 Jun;131(6):803-20
pubmed: 27157931
N Engl J Med. 2015 Jun 25;372(26):2481-98
pubmed: 26061751
World Neurosurg. 2017 Jul;103:180-185
pubmed: 28377251
Int J Radiat Oncol Biol Phys. 2019 Aug 1;104(5):1099-1105
pubmed: 31022510
Science. 2014 Jan 10;343(6167):189-193
pubmed: 24336570
J Clin Oncol. 2013 Jan 20;31(3):344-50
pubmed: 23071237