Suppressor of cytokine signalling 3 is crucial for interleukin-7 receptor re-expression after T-cell activation and interleukin-7 dependent proliferation.
Cell Proliferation
/ physiology
Cytokines
/ metabolism
Down-Regulation
/ physiology
Gene Expression Regulation
/ physiology
Humans
Interleukin-7
/ metabolism
Lymphocyte Activation
/ physiology
Receptors, Interleukin-7
/ metabolism
Signal Transduction
/ physiology
Suppressor of Cytokine Signaling 3 Protein
/ metabolism
Suppressor of Cytokine Signaling Proteins
/ metabolism
T-Lymphocytes
/ metabolism
SOCS3
T-cell activation
interleukin-7
interleukin-7 receptor α-chain
proliferation
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
10
07
2019
revised:
04
09
2019
accepted:
15
10
2019
pubmed:
18
10
2019
medline:
14
7
2020
entrez:
18
10
2019
Statut:
ppublish
Résumé
SOCS3 is a crucial feedback inhibitor of several cytokine pathways with potential regulatory functions during T cell receptor activation. A role of SOCS3 in IL-7-dependent homeostatic mechanisms has been assumed but the underlying mechanisms remain unclear. We investigated the role of SOCS3 in IL-7 receptor α-chain (IL-7Rα) expression and IL-7 effects on activated human CD4
Identifiants
pubmed: 31621896
doi: 10.1002/eji.201948302
doi:
Substances chimiques
Cytokines
0
IL7 protein, human
0
Interleukin-7
0
Receptors, Interleukin-7
0
SOCS3 protein, human
0
Suppressor of Cytokine Signaling 3 Protein
0
Suppressor of Cytokine Signaling Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
234-244Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : JA 1479/5-1
Pays : International
Informations de copyright
© 2019 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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