Chemoreceptors as a key to understanding carcinogenesis process.
Carcinogenesis
Chemoreceptors
Gut breathing fish
Squamous cells proliferation
TOFT theory
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
03
07
2019
revised:
04
10
2019
accepted:
04
10
2019
pubmed:
18
10
2019
medline:
18
12
2020
entrez:
18
10
2019
Statut:
ppublish
Résumé
The tissue organization field theory (TOFT) presented completely new, different from the previous one, perspective of research on neoplasm processes. It implicates that secretory neuroepithelial-like cells (NECs), putative chemoreceptors are probably responsible for the control of squamous epithelial cells proliferation in the digestive tract during hypoxia in gut breathing fish (GBF). On the other hand, chemoreceptors dysfunction can lead to uncontrolled proliferation and risk of cancer development in mammals, including humans. The studies on NECs like cells (signal capturing and transduction) may be crucial for understanding the processes of controlling the proliferation of squamous epithelial cells in the digestive tract of GBF fish during hypoxia states. This knowledge can contribute to the explanation of cancer processes.
Identifiants
pubmed: 31622661
pii: S1044-579X(19)30230-5
doi: 10.1016/j.semcancer.2019.10.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
362-364Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.