Mechanically Induced Periprosthetic Osteolysis: A Systematic Review.
aseptic loosening
osteolysis
revision total joint replacement
total hip replacement
total knee replacement
Journal
HSS journal : the musculoskeletal journal of Hospital for Special Surgery
ISSN: 1556-3316
Titre abrégé: HSS J
Pays: United States
ID NLM: 101273938
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
14
08
2017
accepted:
25
09
2018
entrez:
19
10
2019
pubmed:
19
10
2019
medline:
19
10
2019
Statut:
ppublish
Résumé
Peri-prosthetic bone loss can result from chemical, biological, and mechanical factors. Mechanical stimulation via fluid pressure and flow at the bone-implant interface may be a significant cause. Evidence supporting mechanically induced osteolysis continues to grow, but there is no synthesis of published clinical and basic science data. We sought to review the literature on two questions: (1) What published evidence supports the concept of mechanically induced osteolysis? (2) What is the proposed mechanism of mechanically induced osteolysis, and does it differ from that of particle-induced osteolysis? A systematic review was performed of the PubMed and Web of Science databases. Additional relevant articles were recommended by the senior authors based on their expert opinion. Abstracts were reviewed and the manuscripts pertaining to the study questions were read in full. Studies showing support of mechanically induced osteolysis were quantified and findings summarized. We identified 49 articles of experimental design supporting the hypothesis that mechanical stimulation of peri-prosthetic bone from fluid pressure and flow can induce osteolysis. While the molecular mechanisms may overlap with those implicated in particle-induced osteolysis, mechanically induced osteolysis appears to be mediated by distinct and parallel pathways. The role of mechanical stimuli is increasingly recognized in the pathogenesis of peri-prosthetic osteolysis. Current research aims to elucidate the molecular mechanisms to better target therapeutic interventions.
Sections du résumé
BACKGROUND
BACKGROUND
Peri-prosthetic bone loss can result from chemical, biological, and mechanical factors. Mechanical stimulation via fluid pressure and flow at the bone-implant interface may be a significant cause. Evidence supporting mechanically induced osteolysis continues to grow, but there is no synthesis of published clinical and basic science data.
QUESTIONS/PURPOSES
OBJECTIVE
We sought to review the literature on two questions: (1) What published evidence supports the concept of mechanically induced osteolysis? (2) What is the proposed mechanism of mechanically induced osteolysis, and does it differ from that of particle-induced osteolysis?
METHODS
METHODS
A systematic review was performed of the PubMed and Web of Science databases. Additional relevant articles were recommended by the senior authors based on their expert opinion. Abstracts were reviewed and the manuscripts pertaining to the study questions were read in full. Studies showing support of mechanically induced osteolysis were quantified and findings summarized.
RESULTS
RESULTS
We identified 49 articles of experimental design supporting the hypothesis that mechanical stimulation of peri-prosthetic bone from fluid pressure and flow can induce osteolysis. While the molecular mechanisms may overlap with those implicated in particle-induced osteolysis, mechanically induced osteolysis appears to be mediated by distinct and parallel pathways.
CONCLUSIONS
CONCLUSIONS
The role of mechanical stimuli is increasingly recognized in the pathogenesis of peri-prosthetic osteolysis. Current research aims to elucidate the molecular mechanisms to better target therapeutic interventions.
Identifiants
pubmed: 31624485
doi: 10.1007/s11420-018-9641-5
pii: 9641
pmc: PMC6778158
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
286-296Commentaires et corrections
Type : ErratumIn
Informations de copyright
© Hospital for Special Surgery 2018.
Déclaration de conflit d'intérêts
Conflict of InterestRyan Scully, MD, F. Patrick Ross, PhD, and Anna Falghren, PhD, declare that they have no conflicts of interest. Benjamin A McArthur, MD, reports grants from Orthopedic Research and Education Foundation, during the conduct of the study. Mathias P.G. Bostrom, MD, reports being a paid consultant for Smith & Nephew, outside the submitted work.
Références
Proc Inst Mech Eng H. 2001;215(5):479-86
pubmed: 11726048
Acta Orthop Scand. 1997 Jun;68(3):231-4
pubmed: 9246982
J Bone Joint Surg Am. 2005 Jul;87(7):1522-33
pubmed: 15995120
Acta Orthop. 2006 Dec;77(6):912-6
pubmed: 17260200
J Mech Behav Biomed Mater. 2014 Apr;32:225-244
pubmed: 24495400
J Bone Joint Surg Br. 1995 May;77(3):377-83
pubmed: 7744919
Rev Can Biol. 1975 Mar-Jun;34(1-2):11-22
pubmed: 1178937
J Orthop Res. 2000 May;18(3):481-4
pubmed: 10937637
J Biomed Mater Res B Appl Biomater. 2004 Apr 15;69(1):104-12
pubmed: 15015218
J Biomech. 2016 Jun 14;49(9):1641-1648
pubmed: 27079621
Arch Biochem Biophys. 2008 May 15;473(2):139-46
pubmed: 18395508
J Bone Joint Surg Am. 2009 Jan;91(1):128-33
pubmed: 19122087
J Biomech Eng. 2011 Dec;133(12):121001
pubmed: 22206418
Foot Ankle Surg. 2015 Jun;21(2):132-6
pubmed: 25937414
Bone Rep. 2017 Jul 29;7:17-25
pubmed: 28795083
Acta Biomater. 2013 Sep;9(9):8046-58
pubmed: 23669623
J Bone Joint Surg Br. 2002 Nov;84(8):1093-110
pubmed: 12463652
J Arthroplasty. 2004 Feb;19(2):230-4
pubmed: 14973868
J Bone Joint Surg Br. 2001 Apr;83(3):448-58
pubmed: 11341436
Acta Orthop. 2007 Dec;78(6):795-9
pubmed: 18236186
J Orthop Res. 1992 Mar;10(2):285-99
pubmed: 1311039
Acta Orthop Scand. 1999 Oct;70(5):446-51
pubmed: 10622476
Bone. 2008 Jan;42(1):172-9
pubmed: 17997378
Int J Biochem Cell Biol. 2006;38(9):1540-6
pubmed: 16690344
Bone. 2002 Jan;30(1):171-7
pubmed: 11792581
BMC Med Genet. 2009 Oct 27;10:109
pubmed: 19860911
J Bone Joint Surg Br. 1990 Nov;72(6):971-9
pubmed: 2246300
J Orthop Res. 2003 Mar;21(2):196-201
pubmed: 12568949
Acta Orthop Scand. 1994 Jun;65(3):361-71
pubmed: 8042497
J Bone Joint Surg Br. 1994 May;76(3):432-8
pubmed: 8175848
Comput Methods Biomech Biomed Engin. 2011 Apr;14(4):305-18
pubmed: 21390935
Clin Orthop Relat Res. 1992 Mar;(276):7-18
pubmed: 1537177
Bonekey Rep. 2014 Jan 08;3:481
pubmed: 24466412
Acta Orthop Scand. 2000 Dec;71(6):553-7
pubmed: 11145380
J Biomed Mater Res A. 2012 Jan;100(1):261-8
pubmed: 21987497
Acta Histochem. 2011 Sep;113(5):556-63
pubmed: 20656340
J Arthroplasty. 1997 Oct;12(7):819-24
pubmed: 9355013
J Cell Physiol. 2018 Mar;233(3):2398-2408
pubmed: 28731198
Arch Pharm Res. 2015;38(5):575-84
pubmed: 25648633
Clin Orthop Relat Res. 1998 May;(350):201-8
pubmed: 9602821
J Bone Joint Surg Am. 2007 Apr;89(4):780-5
pubmed: 17403800
J Arthroplasty. 2005 Dec;20(8):1042-8
pubmed: 16376261
Am J Pathol. 1999 Jan;154(1):203-10
pubmed: 9916934
Clin Orthop Relat Res. 1998 Jul;(352):95-104
pubmed: 9678037
J Biomed Mater Res. 1977 Nov;11(6):811-38
pubmed: 591524
J Biomech. 2017 Jun 14;58:1-10
pubmed: 28511839
J Bone Joint Surg Br. 1994 Nov;76(6):912-7
pubmed: 7983118
Int J Oral Surg. 1981 Dec;10(6):387-416
pubmed: 6809663
Acta Orthop Scand. 1992 Apr;63(2):141-5
pubmed: 1590046
Clin Orthop Relat Res. 2001 May;(386):159-65
pubmed: 11347829
J Bone Joint Surg Am. 1992 Jul;74(6):849-63
pubmed: 1634575
Acta Orthop. 2010 Aug;81(4):508-16
pubmed: 20718695
J Cell Biochem. 2012 Apr;113(4):1224-34
pubmed: 22095724
J Dent Res. 2009 Apr;88(4):345-50
pubmed: 19407155
Acta Orthop Scand. 1998 Feb;69(1):1-4
pubmed: 9524506
FASEB J. 1995 Mar;9(5):441-5
pubmed: 7896017
Instr Course Lect. 1996;45:171-82
pubmed: 8727736
Comput Methods Biomech Biomed Engin. 2014;17(16):1809-20
pubmed: 23480611
Clin Orthop Relat Res. 2003 Apr;(409):296-305
pubmed: 12671515
J Orthop Res. 2018 May;36(5):1425-1434
pubmed: 29068483
J Bone Joint Surg Br. 2003 Mar;85(2):288-91
pubmed: 12678371
J Mater Sci Mater Med. 1997 Dec;8(12):785-8
pubmed: 15348791
J Bone Joint Surg Br. 1990 Nov;72(6):966-70
pubmed: 2246299
Clin Orthop Relat Res. 2013 Jun;471(6):1758-62
pubmed: 23463289