Genetic variants of alcohol-metabolizing enzymes in Brugada syndrome: Insights into syncope after drinking alcohol.
Brugada syndrome
alcohol
alcohol‐metabolizing enzymes
polymorphism
syncope
Journal
Journal of arrhythmia
ISSN: 1880-4276
Titre abrégé: J Arrhythm
Pays: Japan
ID NLM: 101263026
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
14
09
2018
revised:
31
07
2019
accepted:
06
08
2019
entrez:
19
10
2019
pubmed:
19
10
2019
medline:
19
10
2019
Statut:
epublish
Résumé
Patients with Brugada syndrome (BrS) are known to have arrhythmic events after alcohol drinking and are recommended to avoid its excessive intake. Mechanisms underlying the alcohol-induced cardiac events are however unknown. This study aimed to test the hypothesis whether activity of alcohol-metabolizing enzymes determines fatal arrhythmic events after drinking alcohol. A total of 198 Japanese patients with BrS were enrolled in this study. These patients were classified into symptomatic (n = 90) and asymptomatic (n = 108) groups. The former was divided into an alcohol-related group (syncope after alcohol drinking, n = 16) and an alcohol-unrelated group (n = 74). Polymerase chain reaction was performed to determine genetic variants of genes encoding alcohol dehydrogenase 1B ( The genotype distribution for Arrhythmic events after alcohol drinking was associated with enhanced activity of alcohol-metabolizing enzyme
Sections du résumé
BACKGROUND
BACKGROUND
Patients with Brugada syndrome (BrS) are known to have arrhythmic events after alcohol drinking and are recommended to avoid its excessive intake. Mechanisms underlying the alcohol-induced cardiac events are however unknown. This study aimed to test the hypothesis whether activity of alcohol-metabolizing enzymes determines fatal arrhythmic events after drinking alcohol.
METHODS
METHODS
A total of 198 Japanese patients with BrS were enrolled in this study. These patients were classified into symptomatic (n = 90) and asymptomatic (n = 108) groups. The former was divided into an alcohol-related group (syncope after alcohol drinking, n = 16) and an alcohol-unrelated group (n = 74). Polymerase chain reaction was performed to determine genetic variants of genes encoding alcohol dehydrogenase 1B (
RESULTS
RESULTS
The genotype distribution for
CONCLUSIONS
CONCLUSIONS
Arrhythmic events after alcohol drinking was associated with enhanced activity of alcohol-metabolizing enzyme
Identifiants
pubmed: 31624517
doi: 10.1002/joa3.12227
pii: JOA312227
pmc: PMC6787161
doi:
Types de publication
Journal Article
Langues
eng
Pagination
752-759Informations de copyright
© 2019 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society.
Déclaration de conflit d'intérêts
Authors declare no conflict of interests for this article.
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