Fibrinogen and Kininogen are Potential Serum Protein Biomarkers for Depressive Disorder.
Journal
Clinical laboratory
ISSN: 1433-6510
Titre abrégé: Clin Lab
Pays: Germany
ID NLM: 9705611
Informations de publication
Date de publication:
01 Oct 2019
01 Oct 2019
Historique:
entrez:
19
10
2019
pubmed:
19
10
2019
medline:
10
3
2020
Statut:
ppublish
Résumé
Depressive disorder is a debilitating psychiatric mental disease. However, no biological methods are used for the diagnosis of this disorder. Proteomic approaches for biomarker discovery may provide an important objective tool for diagnostics of depression. This study aimed to identify serum protein biomarkers for diagnosis of depressive disorder. We screened for potential depression biomarkers in 175 serum samples from 86 patients and 89 healthy controls. Serum protein spectrums were detected by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Differentially expressed peptides among the two groups were analyzed and followed by sequence analysis to identify these peptides. Five peaks were found to have a significant different between the depression and healthy control groups. Among them, up-regulated m/z 1,466.21 and down-regulated m/z 1,944.99 are identified as the fractions of fibrinogen alpha chain and kininogen 1, respectively. Fibrinogen and kininogen may be potential serum protein biomarkers in the diagnosis and prognosis of depressive disorders.
Sections du résumé
BACKGROUND
BACKGROUND
Depressive disorder is a debilitating psychiatric mental disease. However, no biological methods are used for the diagnosis of this disorder. Proteomic approaches for biomarker discovery may provide an important objective tool for diagnostics of depression. This study aimed to identify serum protein biomarkers for diagnosis of depressive disorder.
METHODS
METHODS
We screened for potential depression biomarkers in 175 serum samples from 86 patients and 89 healthy controls. Serum protein spectrums were detected by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Differentially expressed peptides among the two groups were analyzed and followed by sequence analysis to identify these peptides.
RESULTS
RESULTS
Five peaks were found to have a significant different between the depression and healthy control groups. Among them, up-regulated m/z 1,466.21 and down-regulated m/z 1,944.99 are identified as the fractions of fibrinogen alpha chain and kininogen 1, respectively.
CONCLUSIONS
CONCLUSIONS
Fibrinogen and kininogen may be potential serum protein biomarkers in the diagnosis and prognosis of depressive disorders.
Identifiants
pubmed: 31625351
doi: 10.7754/Clin.Lab.2019.190312
doi:
Substances chimiques
Biomarkers
0
Kininogens
0
Proteome
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM