Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults.
C-reactive protein
EGFR protein
chronic renal insufficiency
comorbidity
epidermal growth factor
exercise
follow-up studies
frailty
gait
geriatric nephrology
glomerular filtration rate
hand strength
human
independent living
older persons
phenotype
progression of renal failure
proportional hazards models
receptor
weight loss
Journal
Clinical journal of the American Society of Nephrology : CJASN
ISSN: 1555-905X
Titre abrégé: Clin J Am Soc Nephrol
Pays: United States
ID NLM: 101271570
Informations de publication
Date de publication:
07 11 2019
07 11 2019
Historique:
received:
28
03
2019
accepted:
11
09
2019
pubmed:
20
10
2019
medline:
24
11
2020
entrez:
20
10
2019
Statut:
ppublish
Résumé
Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to investigate whether a fast decline on eGFR would be associated with incident frailty. Community dwellers, aged ≥70, were included in this secondary analysis of the 5-year Multidomain Alzheimer Preventive Trial (MAPT). eGFR was calculated using CKD-Epidemiology Collaboration equation at baseline and at 6, 12, and 24 months. The lowest quartile of eGFR slope (-4.1 ml/min per 1.73 m A total of 833 participants were frail neither at baseline nor at 2 years and had appropriate follow-up data. Median (IQR) baseline eGFR was 73 (61-84) ml/min per 1.73 m In community-dwelling older adults with relatively preserved baseline eGFR, a fast eGFR decline is associated with incident frailty.
Sections du résumé
BACKGROUND AND OBJECTIVES
Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to investigate whether a fast decline on eGFR would be associated with incident frailty.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS
Community dwellers, aged ≥70, were included in this secondary analysis of the 5-year Multidomain Alzheimer Preventive Trial (MAPT). eGFR was calculated using CKD-Epidemiology Collaboration equation at baseline and at 6, 12, and 24 months. The lowest quartile of eGFR slope (-4.1 ml/min per 1.73 m
RESULTS
A total of 833 participants were frail neither at baseline nor at 2 years and had appropriate follow-up data. Median (IQR) baseline eGFR was 73 (61-84) ml/min per 1.73 m
CONCLUSIONS
In community-dwelling older adults with relatively preserved baseline eGFR, a fast eGFR decline is associated with incident frailty.
Identifiants
pubmed: 31628118
pii: 01277230-201911000-00010
doi: 10.2215/CJN.03750319
pmc: PMC6832058
doi:
Banques de données
ClinicalTrials.gov
['NCT00672685']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1597-1604Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 by the American Society of Nephrology.
Références
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K: Frailty in elderly people [published correction appears in Lancet 382: 1328, 2013]. Lancet 381: 752–762, 2013 23395245
Partridge L, Deelen J, Slagboom PE: Facing up to the global challenges of ageing. Nature 561: 45–56, 2018 30185958
Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT; Chronic Kidney Disease Prognosis Consortium: Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: A collaborative meta-analysis. Lancet 375: 2073–2081, 2010 20483451
Fried LF, Lee JS, Shlipak M, Chertow GM, Green C, Ding J, Harris T, Newman AB: Chronic kidney disease and functional limitation in older people: Health, aging and body composition study. J Am Geriatr Soc 54: 750–756, 2006 16696739
Liu CK, Lyass A, Massaro JM, D’Agostino RB Sr., Fox CS, Murabito JM: Chronic kidney disease defined by cystatin C predicts mobility disability and changes in gait speed: The Framingham Offspring Study. J Gerontol A Biol Sci Med Sci 69: 301–307, 2014 23913929
Reese PP, Cappola AR, Shults J, Townsend RR, Gadegbeku CA, Anderson C, Baker JF, Carlow D, Sulik MJ, Lo JC, Go AS, Ky B, Mariani L, Feldman HI, Leonard MB; CRIC Study Investigators: Physical performance and frailty in chronic kidney disease. Am J Nephrol 38: 307–315, 2013 24107579
Ballew SH, Chen Y, Daya NR, Godino JG, Windham BG, McAdams-DeMarco M, Coresh J, Selvin E, Grams ME: Frailty, kidney function, and polypharmacy: The Atherosclerosis Risk in Communities (ARIC) study. Am J Kidney Dis 69: 228–236, 2017 27884475
Dalrymple LS, Katz R, Rifkin DE, Siscovick D, Newman AB, Fried LF, Sarnak MJ, Odden MC, Shlipak MG: Kidney function and prevalent and incident frailty. Clin J Am Soc Nephrol 8: 2091–2099, 2013 24178972
Roderick PJ, Atkins RJ, Smeeth L, Nitsch DM, Hubbard RB, Fletcher AE, Bulpitt CJ: Detecting chronic kidney disease in older people; what are the implications? [published correaction appears in Age Ageing 38: 638, 2009]. Age Ageing 37: 179–186, 2008 18083723
Rifkin DE, Shlipak MG, Katz R, Fried LF, Siscovick D, Chonchol M, Newman AB, Sarnak MJ: Rapid kidney function decline and mortality risk in older adults. Arch Intern Med 168: 2212–2218, 2008 19001197
Shlipak MG, Katz R, Kestenbaum B, Siscovick D, Fried L, Newman A, Rifkin D, Sarnak MJ: Rapid decline of kidney function increases cardiovascular risk in the elderly. J Am Soc Nephrol 20: 2625–2630, 2009 19892934
Helmer C, Stengel B, Metzger M, Froissart M, Massy ZA, Tzourio C, Berr C, Dartigues JF: Chronic kidney disease, cognitive decline, and incident dementia: The 3C study. Neurology 77: 2043–2051, 2011 22116945
Chen YC, Weng SC, Liu JS, Chuang HL, Hsu CC, Tarng DC: Severe decline of estimated glomerular filtration rate associates with progressive cognitive deterioration in the elderly: A community-based cohort study. Sci Rep 7: 42690, 2017 28209982
Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, Bories L, Cufi MN, Dantoine T, Dartigues JF, Desclaux F, Gabelle A, Gasnier Y, Pesce A, Sudres K, Touchon J, Robert P, Rouaud O, Legrand P, Payoux P, Caubere JP, Weiner M, Carrié I, Ousset PJ, Vellas B; MAPT Study Group: Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): A randomised, placebo-controlled trial. Lancet Neurol 16: 377–389, 2017 28359749
Vellas B, Carrie I, Gillette-Guyonnet S, Touchon J, Dantoine T, Dartigues JF, Cuffi MN, Bordes S, Gasnier Y, Robert P, Bories L, Rouaud O, Desclaux F, Sudres K, Bonnefoy M, Pesce A, Dufouil C, Lehericy S, Chupin M, Mangin JF, Payoux P, Adel D, Legrand P, Catheline D, Kanony C, Zaim M, Molinier L, Costa N, Delrieu J, Voisin T, Faisant C, Lala F, Nourhashémi F, Rolland Y, Van Kan GA, Dupuy C, Cantet C, Cestac P, Belleville S, Willis S, Cesari M, Weiner MW, Soto ME, Ousset PJ, Andrieu S: Mapt study: A multidomain approach for preventing Alzheimer’s disease: Design and baseline data. J Prev Alzheimers Dis 1: 13–22, 2014 26594639
Lawton MP: Scales to measure competence in everyday activities. Psychopharmacol Bull 24: 609–614, 1988 3074322
Folstein MF, Folstein SE, McHugh PR: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198, 1975 1202204
Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW: Studies of illness in the aged. the index of adl: A standardized measure of biological and psychosocial function. JAMA 185: 914–919, 1963 14044222
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group: Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56: M146–M156, 2001 11253156
Radloff LS: The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1: 385–401, 1977
Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J; CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration): A new equation to estimate glomerular filtration rate [published correction appears in Ann Intern Med 155: 408, 2011]. Ann Intern Med 150: 604–612, 2009 19414839
Leffondre K, Boucquemont J, Tripepi G, Stel VS, Heinze G, Dunkler D: Analysis of risk factors associated with renal function trajectory over time: A comparison of different statistical approaches. Nephrol Dial Transplant 30: 1237–1243, 2015 25326471
Andrassy KM: Comments on ‘KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease’. Kidney Int 84: 622–623, 2013 23989362
Feng Z, Lugtenberg M, Franse C, Fang X, Hu S, Jin C, Raat H: Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: A systematic review of longitudinal studies. PLoS One 12: e0178383, 2017 28617837
de Souto Barreto P, Rolland Y, Maltais M, Vellas B; MAPT Study Group: Associations of multidomain lifestyle intervention with frailty: Secondary analysis of a randomized controlled trial. Am J Med 131: 1382.e7–1382.e13, 2018 29969614
Bugnicourt JM, Godefroy O, Chillon JM, Choukroun G, Massy ZA: Cognitive disorders and dementia in CKD: The neglected kidney-brain axis. J Am Soc Nephrol 24: 353–363, 2013 23291474
Maltais M, de Souto Barreto P, Moon SY, Rolland Y, Vellas B; MAPT/DSA Study Group: Prospective association of white matter hyperintensity volume and frailty in older adults. Exp Gerontol 118: 51–54, 2019 30639444
Schaap LA, Pluijm SM, Deeg DJ, Visser M: Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 119: 526.e9–526.e17, 2006 16750969
Howren MB, Lamkin DM, Suls J: Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis. Psychosom Med 71: 171–186, 2009 19188531
Amdur RL, Feldman HI, Gupta J, Yang W, Kanetsky P, Shlipak M, Rahman M, Lash JP, Townsend RR, Ojo A, Roy-Chaudhury A, Go AS, Joffe M, He J, Balakrishnan VS, Kimmel PL, Kusek JW, Raj DS; CRIC Study Investigators: Inflammation and progression of CKD: The CRIC study. Clin J Am Soc Nephrol 11: 1546–1556, 2016 27340285
Salimi S, Shardell MD, Seliger SL, Bandinelli S, Guralnik JM, Ferrucci L: Inflammation and trajectory of renal function in community-dwelling older adults. J Am Geriatr Soc 66: 804–811, 2018 29360163
Ju SY, Lee JY, Kim DH: Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: A systematic review and dose-response meta-analysis. BMC Geriatr 18: 206, 2018 30180822
Yenchek R, Ix JH, Rifkin DE, Shlipak MG, Sarnak MJ, Garcia M, Patel KV, Satterfield S, Harris TB, Newman AB, Fried LF; Health, Aging, and Body Composition Study: Association of serum bicarbonate with incident functional limitation in older adults. Clin J Am Soc Nephrol 9: 2111–2116, 2014 25381341
Nixon AC, Bampouras TM, Pendleton N, Woywodt A, Mitra S, Dhaygude A: Frailty and chronic kidney disease: Current evidence and continuing uncertainties. Clin Kidney J 11: 236–245, 2018 29644065
van Loon IN, Goto NA, Boereboom FTJ, Bots ML, Verhaar MC, Hamaker ME: Frailty screening tools for elderly patients incident to dialysis. Clin J Am Soc Nephrol 12: 1480–1488, 2017 28716855
Reid J, Noble HR, Adamson G, Davenport A, Farrington K, Fouque D, Kalantar-Zadeh K, Mallett J, McKeaveney C, Porter S, Seres DS, Shields J, Slee A, Witham MD, Maxwell AP: Establishing a clinical phenotype for cachexia in end stage kidney disease - study protocol. BMC Nephrol 19: 38, 2018 29439674
Farrington K, Covic A, Aucella F, Clyne N, de Vos L, Findlay A, Fouque D, Grodzicki T, Iyasere O, Jager KJ, Joosten H, Macias JF, Mooney A, Nitsch D, Stryckers M, Taal M, Tattersall J, Van Asselt D, Van den Noortgate N, Nistor I, Van Biesen W; ERBP guideline development group: Clinical practice guideline on management of older patients with chronic kidney disease stage 3b or higher (eGFR <45 mL/min/1.73 m 2 ). Nephrol Dial Transplant 31[suppl 2]: ii1–ii66, 2016 27807144
Vinge E, Lindergård B, Nilsson-Ehle P, Grubb A: Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults. Scand J Clin Lab Invest 59: 587–592, 1999 10691049