Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates.
Animals
Biomarkers
/ metabolism
Female
Glucagon-Like Peptide-1 Receptor
/ metabolism
Humans
Ligands
Liver
/ diagnostic imaging
Macaca fascicularis
Male
Peptides
/ metabolism
Positron Emission Tomography Computed Tomography
Protein Binding
Radiometry
Rats
Rats, Sprague-Dawley
Receptors, Glucagon
/ metabolism
Reproducibility of Results
Spleen
/ diagnostic imaging
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 10 2019
18 10 2019
Historique:
received:
19
07
2019
accepted:
02
10
2019
entrez:
20
10
2019
pubmed:
20
10
2019
medline:
15
12
2020
Statut:
epublish
Résumé
The glucagon receptor (GCGR) is an emerging target in anti-diabetic therapy. Reliable biomarkers for in vivo activity on the GCGR, in the setting of dual glucagon-like peptide 1/glucagon (GLP-1/GCG) receptor agonism, are currently unavailable. Here, we investigated [
Identifiants
pubmed: 31628379
doi: 10.1038/s41598-019-51530-0
pii: 10.1038/s41598-019-51530-0
pmc: PMC6800434
doi:
Substances chimiques
Biomarkers
0
Glucagon-Like Peptide-1 Receptor
0
Ligands
0
Peptides
0
Receptors, Glucagon
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14960Références
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