On-site evaluation of CT-based fractional flow reserve using simple boundary conditions for computational fluid dynamics.
Aged
Computed Tomography Angiography
Coronary Angiography
/ methods
Coronary Artery Disease
/ diagnostic imaging
Coronary Vessels
/ diagnostic imaging
Female
Fractional Flow Reserve, Myocardial
Humans
Hydrodynamics
Male
Middle Aged
Models, Cardiovascular
Patient-Specific Modeling
Predictive Value of Tests
Reproducibility of Results
Retrospective Studies
Computational fluid dynamics
Computed tomography
Coronary physiology
Fractional flow reserve
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
31
05
2019
accepted:
09
10
2019
pubmed:
20
10
2019
medline:
5
3
2020
entrez:
20
10
2019
Statut:
ppublish
Résumé
Fractional flow reserve (FFR) is an established method for diagnosing physiological coronary artery stenosis. A method for computing FFR using coronary computed tomography (CT) images was recently developed. However, its calculation requires off-site supercomputer analysis. Here, we report the preliminary result of a method using simple estimation of boundary conditions. The lumen boundaries of the coronary arteries were semi-automatically delineated using full width at half maximum of CT number profiles. The computational fluid dynamics (CFD) of the blood flow was performed using the boundary conditions of a fixed pressure at the coronary ostium and flow rates at each outlet. The total inflow at the coronary ostium was estimated based on the uniform wall shear stress hypothesis and corrected using a hyperemic multiplier to gain a hyperemic flow rate. The flow distribution from a parent vessel to the downstream daughter vessels was determined according to Murray's law. FFR estimated by CFD was calculated as FFR
Identifiants
pubmed: 31628575
doi: 10.1007/s10554-019-01709-3
pii: 10.1007/s10554-019-01709-3
doi:
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
337-346Références
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