Suppression of Glucagon-Like Peptide-1 Release by Inhibition of Intestinal NLRP3 Inflammasome Activation in Asc
GLP-1
HMGB1
IL-1β
NLRP3
inflammasome
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
06
2019
accepted:
06
09
2019
entrez:
22
10
2019
pubmed:
22
10
2019
medline:
22
10
2019
Statut:
epublish
Résumé
The glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone secreted by intestinal enteroendocrine L-cells, which plays a crucial role in glucose control, regulation, and protection from different pathological conditions such as diabetes mellitus. The present study sought to test whether GLP-1 release increases gut injury with a high-fat diet (HFD) and whether this GLP-1 release is associated with NLRP3 inflammasome activation. Our results showed that the NLRP3 inflammasome is activated in the intestinal tissue of wild-type mice on a HFD, accompanied by GLP-1 overexpression. The number of intestinal L-cells and the GLP-1 level in serum are increased in WT mice with HFD. However, in the Asc
Identifiants
pubmed: 31632284
doi: 10.3389/fphys.2019.01213
pmc: PMC6779826
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1213Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK120491
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL057244
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL075316
Pays : United States
Informations de copyright
Copyright © 2019 Chen, Kidd, Bhat, Yuan, Hong, He and Li.
Références
Nature. 2012 Feb 01;482(7384):179-85
pubmed: 22297845
Cell Metab. 2017 May 2;25(5):1075-1090.e5
pubmed: 28467926
Am J Transl Res. 2013 Apr 19;5(3):347-58
pubmed: 23634245
Am J Physiol Gastrointest Liver Physiol. 2015 Nov 15;309(10):G807-15
pubmed: 26336929
Diabetes. 2014 Oct;63(10):3221-9
pubmed: 24947356
J Diabetes Res. 2017;2017:6519785
pubmed: 29435463
J Nutr Biochem. 2013 Oct;24(10):1663-77
pubmed: 24041374
Mediators Inflamm. 2015;2015:936193
pubmed: 25821356
Biochim Biophys Acta. 2014 May;1843(5):836-45
pubmed: 24508291
Nat Immunol. 2011 May;12(5):408-15
pubmed: 21478880
Biochem Biophys Res Commun. 2018 Oct 28;505(2):523-529
pubmed: 30269815
Nat Commun. 2014 Dec 23;5:5864
pubmed: 25536194
Hepatology. 2014 May;59(5):1738-49
pubmed: 23959503
Hepatology. 2013 Jul;58(1):351-62
pubmed: 23408710
Nat Med. 2011 Feb;17(2):179-88
pubmed: 21217695
Front Immunol. 2017 Sep 20;8:1168
pubmed: 28979266
Int J Med Sci. 2017 Sep 19;14(12):1203-1212
pubmed: 29104476
Am J Pathol. 2014 May;184(5):1617-28
pubmed: 24631027
Mol Med Rep. 2017 Jul;16(1):929-936
pubmed: 28560433
Front Immunol. 2016 Apr 22;7:154
pubmed: 27148273
Sci Rep. 2017 Sep 22;7(1):12200
pubmed: 28939830
Oxid Med Cell Longev. 2018 Jul 22;2018:2901871
pubmed: 30140364
Immunology. 2019 Jun;157(2):95-109
pubmed: 30851192