Lipidomic characterization of extracellular vesicles in human serum.
Extracellular vesicle
blood
exosome
lipid
lipidomics
serum
Journal
Journal of circulating biomarkers
ISSN: 1849-4544
Titre abrégé: J Circ Biomark
Pays: United States
ID NLM: 101703517
Informations de publication
Date de publication:
Historique:
received:
27
09
2018
accepted:
03
09
2019
entrez:
22
10
2019
pubmed:
22
10
2019
medline:
22
10
2019
Statut:
epublish
Résumé
There is a wide variety of extracellular vesicles (EVs) that differ in size and cargo composition. EVs isolated from human plasma or serum carry lipid, protein, and RNA cargo that provides insights to the regulation of normal physiological processes, and to pathological states. Specific populations of EVs have been proposed to contain protein and RNA cargo that are biomarkers for neurologic and systemic diseases. Although there is a considerable amount of evidence that circulating lipids are biomarkers for multiple disease states, it not clear if these lipid biomarkers are enriched in EVs, or if specific populations of EVs are enriched for particular classes of lipid. A highly reproducible workflow for the analysis of lipid content in EVs isolated from human plasma or serum would facilitate this area of research. Here we optimized an MS/MS
Identifiants
pubmed: 31632506
doi: 10.1177/1849454419879848
pii: 10.1177_1849454419879848
pmc: PMC6769212
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1849454419879848Subventions
Organisme : NIA NIH HHS
ID : R01 AG057420
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA040390
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH075673
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH077542
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110246
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH096636
Pays : United States
Organisme : NIMH NIH HHS
ID : P01 MH105280
Pays : United States
Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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