Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS.

FOXP3 KRAS Tregs cell-extrinsic lung cancer phenotypic switching

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
18 Oct 2019
Historique:
received: 12 09 2019
revised: 09 10 2019
accepted: 15 10 2019
entrez: 23 10 2019
pubmed: 23 10 2019
medline: 23 10 2019
Statut: epublish

Résumé

Oncogenic (mutant) Ras protein Kirsten rat sarcoma viral oncogene homolog (KRAS) promotes uncontrolled proliferation, altered metabolism, and loss of genome integrity in a cell-intrinsic manner. Here, we demonstrate that CD4

Identifiants

pubmed: 31635338
pii: jcm8101726
doi: 10.3390/jcm8101726
pmc: PMC6832522
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA209978
Pays : United States
Organisme : NIH HHS
ID : U54CA209978
Pays : United States
Organisme : NCI NIH HHS
ID : P30CA033572
Pays : United States

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Auteurs

Arjun Kalvala (A)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. akalvala@coh.org.

Pierre Wallet (P)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. pwallet@coh.org.

Lu Yang (L)

Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. luyang@coh.org.

Chongkai Wang (C)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. chowang@coh.org.

Haiqing Li (H)

Center for Informatics, City of Hope National Medical Center, Duarte, CA 91010, USA. hali@coh.org.
Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. hali@coh.org.

Arin Nam (A)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. anam@coh.org.

Anusha Nathan (A)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. anathan@coh.org.

Isa Mambetsariev (I)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. Imambetsariev@coh.org.

Valeriy Poroyko (V)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. vporoyko@coh.org.

Hanlin Gao (H)

Fulgent Genetics, 4978 Santa Anita Avenue, Temple City, CA 91780, USA. harrygao@fulgentgenetics.com.

Peiguo Chu (P)

Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA. PChu@coh.org.

Martin Sattler (M)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Martin_Sattler@dfci.harvard.edu.

Andrea Bild (A)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. abild@coh.org.

Edwin R Manuel (ER)

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA. EManuel@coh.org.

Peter P Lee (PP)

Department of Immuno-Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA. plee@coh.org.

Mohit Kumar Jolly (MK)

Center for BioSystems Science and Engineering, Indian Institute of Science, 560012 Bangalore, India. mkjolly.15@gmail.com.

Prakash Kulkarni (P)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. pkulkarni@coh.org.

Ravi Salgia (R)

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA. rsalgia@coh.org.

Classifications MeSH