The Oncogenic Signaling Pathways in
Cell Line, Tumor
Cell Survival
/ drug effects
Circular Dichroism
G-Quadruplexes
/ drug effects
Gene Expression Regulation, Neoplastic
/ genetics
Humans
Imides
/ therapeutic use
Melanoma
/ genetics
Naphthalenes
/ therapeutic use
Proto-Oncogene Proteins B-raf
/ genetics
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-kit
/ genetics
Signal Transduction
/ genetics
BCL-2
G-quadruplex
KIT
melanoma
naphthalene diimides
oncogene promoter
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
18 10 2019
18 10 2019
Historique:
received:
25
07
2019
revised:
27
09
2019
accepted:
16
10
2019
entrez:
23
10
2019
pubmed:
23
10
2019
medline:
7
7
2020
Statut:
epublish
Résumé
Melanoma is the most aggressive and deadly type of skin cancer. Despite the advent of targeted therapies directed against specific oncogene mutations, melanoma remains a tumor that is very difficult to treat, and ultimately remains incurable. In the past two decades, stabilization of the non-canonical nucleic acid G-quadruplex structures within oncogene promoters has stood out as a promising approach to interfere with oncogenic signaling pathways in cancer cells, paving the way toward the development of G-quadruplex ligands as antitumor drugs. Here, we present the synthesis and screening of a library of differently functionalized core-extended naphthalene diimides for their activity against the
Identifiants
pubmed: 31635389
pii: cells8101274
doi: 10.3390/cells8101274
pmc: PMC6830342
pii:
doi:
Substances chimiques
Imides
0
Naphthalenes
0
Proto-Oncogene Proteins c-bcl-2
0
naphthalenediimide
22291-04-9
KIT protein, human
EC 2.7.10.1
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 615879
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest
Références
Anticancer Res. 2017 Nov;37(11):5941-5953
pubmed: 29061773
Oncogene. 2015 Mar 5;34(10):1292-9
pubmed: 24662821
Curr Opin Struct Biol. 2009 Jun;19(3):239-50
pubmed: 19487118
J Med Chem. 2013 Aug 22;56(16):6521-30
pubmed: 23865750
Chem Biol. 2013 Mar 21;20(3):341-50
pubmed: 23521792
Nucleic Acids Res. 2018 Nov 2;46(19):e115
pubmed: 29986058
Cancers (Basel). 2018 May 24;10(6):null
pubmed: 29795041
Cancer Metastasis Rev. 2017 Mar;36(1):53-75
pubmed: 28210865
Nature. 2013 May 23;497(7450):458-62
pubmed: 23657261
Nucleic Acids Res. 2016 Mar 18;44(5):1989-2006
pubmed: 26883636
J Med Chem. 2018 Oct 11;61(19):8625-8638
pubmed: 30188709
EMBO Mol Med. 2018 Jan;10(1):22-31
pubmed: 29113975
DNA Repair (Amst). 2015 Jan;25:104-15
pubmed: 25467559
Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):313-322
pubmed: 30776401
J Clin Oncol. 2013 Sep 10;31(26):3288-90
pubmed: 23940224
J Am Chem Soc. 2015 Feb 25;137(7):2424-7
pubmed: 25654467
Nat Rev Drug Discov. 2011 Apr;10(4):261-75
pubmed: 21455236
Int J Oncol. 2015 Jan;46(1):369-80
pubmed: 25370864
Nat Protoc. 2006;1(6):2527-35
pubmed: 17406506
Sci Rep. 2017 Mar 24;7:45244
pubmed: 28338097
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11593-8
pubmed: 12195017
J Am Chem Soc. 2013 Dec 26;135(51):19319-29
pubmed: 24295054
Nucleic Acids Res. 2006;34(19):5402-15
pubmed: 17012276
Curr Genomics. 2008 Sep;9(6):409-19
pubmed: 19506730
Nat Genet. 2016 Oct;48(10):1267-72
pubmed: 27618450
Curr Pharm Des. 2016;22(44):6612-6624
pubmed: 27587203
J Invest Dermatol. 2015 Sep;135(9):2155-2161
pubmed: 25947358
Nat Chem. 2013 Mar;5(3):182-6
pubmed: 23422559
Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):615-629
pubmed: 29229300
Methods. 2007 Dec;43(4):291-301
pubmed: 17967699
Met Ions Life Sci. 2012;10:119-34
pubmed: 22210337
Eur J Med Chem. 2018 Jan 1;143:1277-1300
pubmed: 29126724
Sci Rep. 2018 Feb 5;8(1):2366
pubmed: 29402965
J Am Chem Soc. 2005 Aug 3;127(30):10584-9
pubmed: 16045346
Curr Drug Targets. 2015;16(3):233-48
pubmed: 25654738
Nucleic Acids Res. 2019 Jun 20;47(11):5502-5510
pubmed: 30949698
FEBS J. 2010 Mar;277(5):1118-25
pubmed: 19951354
Nat Rev Drug Discov. 2012 Nov;11(11):873-86
pubmed: 23060265
J Am Chem Soc. 2014 Feb 5;136(5):1750-3
pubmed: 24450880
Nat Commun. 2019 Jan 11;10(1):137
pubmed: 30635584
Nucleic Acids Res. 2014 Jan;42(2):860-9
pubmed: 24163102
Biochemistry. 2006 Jun 27;45(25):7854-60
pubmed: 16784237
Nat Commun. 2018 Nov 9;9(1):4730
pubmed: 30413703
Nat Commun. 2017 Feb 17;8:14432
pubmed: 28211448
J Med Chem. 2015 Dec 24;58(24):9639-52
pubmed: 26599611
FEBS J. 2010 Sep;277(17):3459-69
pubmed: 20670278
FEBS J. 2010 Sep;277(17):3452-8
pubmed: 20670279
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Cancer J. 2017 Jan/Feb;23(1):54-58
pubmed: 28114255
Molecules. 2019 Jan 24;24(3):null
pubmed: 30682828
Nucleic Acids Res. 2015 Oct 15;43(18):8627-37
pubmed: 26350216
Org Biomol Chem. 2008 Feb 21;6(4):627-36
pubmed: 18264563
Org Biomol Chem. 2012 Apr 14;10(14):2798-806
pubmed: 22367401
Nucleic Acids Res. 2015 Apr 30;43(8):4039-54
pubmed: 25813041
Nucleic Acids Res. 2007;35(2):406-13
pubmed: 17169996