Malignancy and myositis, from molecular mimicry to tumor infiltrating lymphocytes.
Autoimmunity
Cancer
Dermatomyositis
Molecular mimicry
Myositis
PD-1/PD-L1 tumor-infiltrating lymphocytes
Journal
Neuromuscular disorders : NMD
ISSN: 1873-2364
Titre abrégé: Neuromuscul Disord
Pays: England
ID NLM: 9111470
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
06
06
2019
revised:
21
09
2019
accepted:
23
09
2019
pubmed:
23
10
2019
medline:
7
7
2020
entrez:
23
10
2019
Statut:
ppublish
Résumé
Cancer-associated dermatomyositis provides a unique opportunity to explore the relationship between autoimmunity and cancer. In this review, we describe the related epidemiological issues, considering the various currently accepted myositis phenotypes, their link with cancer, and the possible mechanisms leading to this relationship. We discuss current evidence regarding the role of molecular mimicry, somatic DNA tumor mutations, and the PD-1/PD-L1 pathway in the association between cancer and myositis. We also review tumor-infiltrating lymphocytes as a relevant factor to be evaluated in cancer-associated myositis, their interaction with tumor neoantigens, and the tumor mutational burden, all of which have implications for the treatment of these patients with immunotherapy. Finally, we discuss clinical scenarios related to the relationship between cancer and myositis, delineating a comprehensive theory linking autoimmunity and cancer.
Identifiants
pubmed: 31635909
pii: S0960-8966(19)31134-4
doi: 10.1016/j.nmd.2019.09.014
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
819-825Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.