Platelets in Inflammation and Resolution.

Blood Platelets / physiology Cell Communication Extracellular Vesicles / physiology Hemostasis Humans Inflammasomes / physiology Inflammation / etiology Leukocytes / physiology Platelet Count

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 29 07 2019
accepted: 30 08 2019
entrez: 23 10 2019
pubmed: 23 10 2019
medline: 29 5 2020
Statut: ppublish

Résumé

Platelets have long been known for their role in hemostasis. In this, platelet adhesion and activation leads to the formation of a firm thrombus and thus the sealing of a damaged blood vessel. More recently, inflammatory modes of function have been attributed to these non-nuclei-containing cellular fragments. Interaction with leukocytes, secretion of proinflammatory mediators, and migratory behavior are some of the recent discoveries. Nonetheless, platelets also have anti-inflammatory potential by regulating macrophage functions, regulatory T cells, and secretion of proresolving mediators. This review summarizes current knowledge of platelet functions with a special focus on inflammation and resolution of inflammation.

Identifiants

DOI: 10.4049/jimmunol.1900899 PMID: 31636134
pubmed: 31636134
pii: 203/9/2357
doi: 10.4049/jimmunol.1900899
doi:

Substances chimiques

Inflammasomes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

2357-2367

Informations de copyright

Copyright © 2019 by The American Association of Immunologists, Inc.

Auteurs

Andreas Margraf (A)

Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, 48149 Muenster, Germany.
ORCID: 0000-0002-6539-6478

Alexander Zarbock (A)

Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, 48149 Muenster, Germany zarbock@uni-muenster.de.
ORCID: 0000-0002-2124-1714

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Platelets in Inflammation and Resolution.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › Platelets in Inflammation and Resolution.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Platelets in Inflammation and Resolution.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Platelets in Inflammation and Resolution.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Platelets in Inflammation and Resolution.
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Platelets in Inflammation and Resolution.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Platelets in Inflammation and Resolution.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Platelets in Inflammation and Resolution.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémogramme › Numération des plaquettes › Platelets in Inflammation and Resolution.