NMR-based metabolomics in pediatric drug resistant epilepsy - preliminary results.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 10 2019
21 10 2019
Historique:
received:
21
02
2019
accepted:
16
09
2019
entrez:
23
10
2019
pubmed:
23
10
2019
medline:
31
10
2020
Statut:
epublish
Résumé
Epilepsy in children is the most frequent, heterogeneous and difficult to classify chronic neurologic condition with the etiology found in 35-40% of patients. Our aim is to detect the metabolic differences between the epileptic children and the children with no neurological abnormalities in order to define the metabolic background for therapy monitoring. The studied group included 28 epilepsy patients (median age 12 months) examined with a diagnostic protocol including EEG, videoEEG, 24-hour-EEG, tests for inborn errors of metabolism, chromosomal analysis and molecular study. The reference group consisted of 20 patients (median age 20 months) with no neurological symptoms, no development delay nor chronic diseases.
Identifiants
pubmed: 31636291
doi: 10.1038/s41598-019-51337-z
pii: 10.1038/s41598-019-51337-z
pmc: PMC6803684
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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