The Prognostic Values of a Novel Preoperative Inflammation-Based Score in Japanese Patients With Non-Small Cell Lung Cancer.
Cancer-specific survival
Non-small cell lung cancer
Novel inflammation-based core
Surgery
Journal
World journal of oncology
ISSN: 1920-454X
Titre abrégé: World J Oncol
Pays: Canada
ID NLM: 101564097
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
01
08
2019
accepted:
19
08
2019
entrez:
23
10
2019
pubmed:
23
10
2019
medline:
23
10
2019
Statut:
ppublish
Résumé
Several previous researchers have investigated the prognostic value of the combinations of systemic inflammatory markers. However, the prognostic power of these systemic inflammatory markers is not identical. We aimed to establish a novel prognostic score based on systemic inflammatory markers. Four hundred non-small cell lung cancer (NSCLC) patients who underwent surgery and were followed more than 5 years were included. Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model. Among systemic inflammatory markers which were used for the previously reported indexes, preoperative serum C-reactive protein (CRP) and body mass index (BMI) were independent prognostic markers in multivariate analysis, while serum albumin level, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were not. Based on this result, a novel score was established. Patients with both normal CRP (< 0.13 ng/dL) and high BMI (> 20.6 kg/m This novel score based on CRP and BMI might serve as an efficient prognostic indicator in resected NSCLC.
Sections du résumé
BACKGROUND
BACKGROUND
Several previous researchers have investigated the prognostic value of the combinations of systemic inflammatory markers. However, the prognostic power of these systemic inflammatory markers is not identical. We aimed to establish a novel prognostic score based on systemic inflammatory markers.
METHODS
METHODS
Four hundred non-small cell lung cancer (NSCLC) patients who underwent surgery and were followed more than 5 years were included. Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model.
RESULTS
RESULTS
Among systemic inflammatory markers which were used for the previously reported indexes, preoperative serum C-reactive protein (CRP) and body mass index (BMI) were independent prognostic markers in multivariate analysis, while serum albumin level, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were not. Based on this result, a novel score was established. Patients with both normal CRP (< 0.13 ng/dL) and high BMI (> 20.6 kg/m
CONCLUSION
CONCLUSIONS
This novel score based on CRP and BMI might serve as an efficient prognostic indicator in resected NSCLC.
Identifiants
pubmed: 31636791
doi: 10.14740/wjon1222
pmc: PMC6785273
doi:
Types de publication
Journal Article
Langues
eng
Pagination
176-180Informations de copyright
Copyright 2019, Tomita et al.
Déclaration de conflit d'intérêts
The authors have declared that no conflict of interest exists.
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