Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314.
cornea
drug toxicity/drug effect
refractive surgery
trauma
wound healing
Journal
Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
06
05
2019
accepted:
15
08
2019
entrez:
23
10
2019
pubmed:
23
10
2019
medline:
23
10
2019
Statut:
epublish
Résumé
Topical corneal local anesthetics are short acting and may impair corneal healing. In this study we compared corneal anesthesia and toxicity of topically applied Various concentrations of QX-314 and 15 mM (0.5%) PPC were topically applied to rat corneas. Corneal anesthesia was assessed with a Cochet-Bonnet esthesiometer at predetermined time points. PC12 cells were exposed to the same solutions to assess cytotoxicity. Repeated topical corneal administration in rats was then used to assess for histologic evidence of toxicity. Finally, we created uniform corneal epithelial defects in rats and assessed the effect of repeated administration of these compounds on the defect healing rate. QX-314 (15 mM) and PPC (15 mM) caused similar total duration (114 ± 17 and 87 ± 16 minutes, respectively; Topical administration of QX-314 is effective for corneal anesthesia and demonstrates no histologic signs of local toxicity in a rodent model. In higher concentrations, QX-314 provides more than twofold the duration of anesthetic effect than does 0.5% PPC. Our study reveals a clinically relevant compound providing prolonged duration topical corneal anesthesia.
Identifiants
pubmed: 31637108
doi: 10.1167/tvst.8.5.28
pii: TVST-19-1608
pmc: PMC6798327
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28Informations de copyright
Copyright 2019 The Authors.
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