Predictors of Clinical Success After Surgery for Primary Aldosteronism in the Japanese Nationwide Cohort.
cure
hypertension
improvement
predictive model
primary aldosteronism
surgery
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Nov 2019
01 Nov 2019
Historique:
received:
02
08
2019
accepted:
16
08
2019
entrez:
23
10
2019
pubmed:
23
10
2019
medline:
23
10
2019
Statut:
epublish
Résumé
Aldosterone-producing adenomas are a curable subtype of primary aldosteronism (PA); however, hypertension persists in some patients after adrenalectomy. To identify factors associated with, and develop prediction models for, blood pressure (BP) normalization or improvement after adrenalectomy. Retrospective analysis of patients treated between 2006 and 2018, with a 6-month follow-up. A nationwide, 29-center Japanese registry encompassing 15 university hospitals and 14 city hospitals. We categorized 574 participants in the Japan Primary Aldosteronism Study, who were diagnosed with PA and underwent adrenalectomy, as BP normalized or improved, on the basis of their presentations at 6 months postsurgery. The rate of complete, partial, and absent clinical success. Predictive factors related to BP outcomes after PA surgery were also evaluated. Complete clinical success was achieved in 32.6% and partial clinical success was achieved in 53.0% of the patients at 6 months postsurgery. The following five variables were independent predictors for BP normalization: ≤7 years of hypertension, body mass index ≤25 kg/m We established models that predicted postoperative BP normalization in patients with PA. These should be useful for shared decision-making regarding adrenalectomy for PA.
Identifiants
pubmed: 31637342
doi: 10.1210/js.2019-00295
pii: 201900295
pmc: PMC6795022
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2012-2022Informations de copyright
Copyright © 2019 Endocrine Society.
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