Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages.
Animals
Anti-Bacterial Agents
/ pharmacology
Antimycin A
/ pharmacology
Caspases, Initiator
/ genetics
Cells, Cultured
Macrophages
/ immunology
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
Reactive Oxygen Species
/ metabolism
Staphylococcal Infections
/ immunology
Vacuoles
/ metabolism
ROS
Staphylococcus aureus
caspase-11
macrophages
mitochondria
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 12 2019
05 12 2019
Historique:
received:
17
03
2019
revised:
16
09
2019
accepted:
25
09
2019
pubmed:
23
10
2019
medline:
22
5
2020
entrez:
23
10
2019
Statut:
ppublish
Résumé
Methicillin-resistant Staphylococcus aureus (MRSA) is a growing health concern due to increasing resistance to antibiotics. As a facultative intracellular pathogen, MRSA is capable of persisting within professional phagocytes including macrophages. Here, we identify a role for CASP11 in facilitating MRSA survival within murine macrophages. We show that MRSA actively prevents the recruitment of mitochondria to the vicinity of the vacuoles they reside in to avoid intracellular demise. This process requires CASP11 since its deficiency allows increased association of MRSA-containing vacuoles with mitochondria. The induction of mitochondrial superoxide by antimycin A (Ant A) improves MRSA eradication in casp11
Identifiants
pubmed: 31637841
doi: 10.15252/embr.201948109
pmc: PMC6893291
doi:
Substances chimiques
Anti-Bacterial Agents
0
Reactive Oxygen Species
0
Antimycin A
642-15-9
Casp4 protein, mouse
EC 3.4.22.-
Caspases, Initiator
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e48109Subventions
Organisme : HHS|NIH|National Heart, Lung, and Blood Institute (NHLBI)
ID : HL127651-01A1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL127651
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124121
Pays : United States
Organisme : Egyptian Bureau of Education
Pays : International
Organisme : Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID)
ID : AI24121
Pays : International
Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
Références
Cell Microbiol. 2016 Jan;18(1):80-96
pubmed: 26248337
J Clin Invest. 2017 Nov 1;127(11):4124-4135
pubmed: 28990935
J Immunol. 2000 Apr 1;164(7):3713-22
pubmed: 10725730
Nature. 2016 Jul 06;535(7610):153-8
pubmed: 27383986
Front Microbiol. 2017 Jul 19;8:1354
pubmed: 28769913
Clin Microbiol Rev. 1997 Oct;10(4):781-91
pubmed: 9336672
Cell. 1998 Feb 20;92(4):501-9
pubmed: 9491891
EMBO Rep. 2019 Dec 5;20(12):e48109
pubmed: 31637841
PLoS Pathog. 2013;9(6):e1003400
pubmed: 23762026
J Biol Chem. 2010 Apr 2;285(14):10850-61
pubmed: 20123989
Mol Cell. 2012 Apr 27;46(2):200-11
pubmed: 22464733
Autophagy. 2012 Dec;8(12):1865-7
pubmed: 23047465
J Biol Chem. 2013 Jan 18;288(3):2049-58
pubmed: 23148214
Aging Cell. 2019 Jun;18(3):e12946
pubmed: 30916891
Cell Rep. 2018 Aug 7;24(6):1425-1433
pubmed: 30089254
Autophagy. 2011 Nov;7(11):1359-70
pubmed: 21997369
Autophagy. 2018;14(5):921-924
pubmed: 29458285
Nature. 2014 Oct 9;514(7521):187-92
pubmed: 25119034
J Immunol. 2018 May 1;200(9):3047-3052
pubmed: 29602772
Science. 2013 Feb 22;339(6122):975-8
pubmed: 23348507
J Comp Neurol. 2000 Nov 20;427(3):351-61
pubmed: 11054698
Nat Immunol. 2013 Jun;14(6):543-53
pubmed: 23644505
J Biol Chem. 2016 Apr 15;291(16):8701-8
pubmed: 26893374
Immunity. 2013 Aug 22;39(2):311-323
pubmed: 23954133
Front Cell Infect Microbiol. 2012 Mar 16;2:33
pubmed: 22919625
Cell Rep. 2018 Feb 27;22(9):2431-2441
pubmed: 29490278
Pathogens. 2015 Nov 27;4(4):826-68
pubmed: 26633519
Nature. 2006 Mar 9;440(7081):228-32
pubmed: 16407890
Genes Dev. 2007 Aug 1;21(15):1909-20
pubmed: 17671090
Infect Immun. 2002 May;70(5):2657-64
pubmed: 11953408
PLoS Pathog. 2012;8(7):e1002628
pubmed: 22807671
Nature. 2011 Apr 28;472(7344):476-80
pubmed: 21525932
Infect Immun. 2015 Oct 26;84(1):241-53
pubmed: 26502911
Infect Immun. 2015 Sep;83(9):3445-57
pubmed: 26099586
mSphere. 2018 Aug 8;3(4):
pubmed: 30089650
J Immunol. 2009 Sep 15;183(6):3942-8
pubmed: 19717510
Immunity. 2018 Jan 16;48(1):35-44.e6
pubmed: 29195811
Cell Host Microbe. 2018 Nov 14;24(5):625-636.e5
pubmed: 30449314
Cell Host Microbe. 2015 Nov 11;18(5):604-12
pubmed: 26567511
Chem Biol. 2011 Nov 23;18(11):1474-81
pubmed: 22118681
PLoS One. 2009 Oct 14;4(10):e7446
pubmed: 19826485
Cell Res. 2015 Dec;25(12):1285-98
pubmed: 26611636
Cell. 2018 Nov 29;175(6):1651-1664.e14
pubmed: 30392956
J Infect Dis. 2012 Mar 1;205(5):807-17
pubmed: 22279123
Eur J Immunol. 2015 Oct;45(10):2918-26
pubmed: 26173988
Sci Rep. 2015 Dec 21;5:18479
pubmed: 26686473
Nature. 2015 Oct 29;526(7575):666-71
pubmed: 26375259
Mol Cell Proteomics. 2008 Dec;7(12):2350-63
pubmed: 18667412
Cell Rep. 2016 Aug 23;16(8):2219-2230
pubmed: 27524612
J Leukoc Biol. 1996 Apr;59(4):471-5
pubmed: 8613691
Nature. 2011 Oct 16;479(7371):117-21
pubmed: 22002608
Immunity. 2012 Jul 27;37(1):35-47
pubmed: 22658523
PLoS Pathog. 2015 Jun 12;11(6):e1004970
pubmed: 26069969
EMBO J. 2016 Aug 15;35(16):1766-78
pubmed: 27418190
Antimicrob Agents Chemother. 2015 Dec 28;60(3):1521-9
pubmed: 26711769
J Neurochem. 2014 May;129(4):704-11
pubmed: 24484406
J Immunol. 2013 Nov 15;191(10):5230-8
pubmed: 24089192
Autophagy. 2018;14(11):1928-1942
pubmed: 30165781
Cell. 2013 Apr 25;153(3):521-34
pubmed: 23582643
PLoS Pathog. 2014 Mar 13;10(3):e1003986
pubmed: 24626296
Nat Immunol. 2016 Sep;17(9):1037-1045
pubmed: 27348412
Science. 2013 Sep 13;341(6151):1250-3
pubmed: 24031018
J Leukoc Biol. 2012 Nov;92(5):1069-81
pubmed: 22892107
Eur J Biochem. 1997 Jan 15;243(1-2):240-6
pubmed: 9030745
Cell Microbiol. 2016 Apr;18(4):514-35
pubmed: 26408990
PLoS One. 2008 Jan 09;3(1):e1409
pubmed: 18183290
J Infect Dis. 2012 May 15;205(10):1571-9
pubmed: 22457275
Sci Prog. 2002;85(Pt 1):57-72
pubmed: 11969119
Nature. 2011 Jan 13;469(7329):221-5
pubmed: 21124315
Virulence. 2017 Nov 17;8(8):1761-1775
pubmed: 28762868
PLoS Pathog. 2009 Apr;5(4):e1000361
pubmed: 19343209
J Biol Chem. 2007 Jan 26;282(4):2695-706
pubmed: 17135247
J Cell Sci. 2005 Dec 1;118(Pt 23):5411-9
pubmed: 16306220
Nat Cell Biol. 2007 Mar;9(3):276-86
pubmed: 17293856
J Biol Chem. 1993 Dec 5;268(34):25568-76
pubmed: 8244994
PLoS Pathog. 2015 Apr 16;11(4):e1004820
pubmed: 25880560