Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.
GDF11
adiponectin
aging
calorie restriction
heterochronic parabiosis
rejuvenation
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
28
01
2019
revised:
06
07
2019
accepted:
19
08
2019
pubmed:
23
10
2019
medline:
14
1
2021
entrez:
23
10
2019
Statut:
ppublish
Résumé
Aging is a negative regulator of general homeostasis, tissue function, and regeneration. Changes in organismal energy levels and physiology, through systemic manipulations such as calorie restriction and young blood infusion, can regenerate tissue activity and increase lifespan in aged mice. However, whether these two systemic manipulations could be linked has never been investigated. Here, we report that systemic GDF11 triggers a calorie restriction-like phenotype without affecting appetite or GDF15 levels in the blood, restores the insulin/IGF-1 signaling pathway, and stimulates adiponectin secretion from white adipose tissue by direct action on adipocytes, while repairing neurogenesis in the aged brain. These findings suggest that GDF11 has a pleiotropic effect on an organismal level and that it could be a linking mechanism of rejuvenation between heterochronic parabiosis and calorie restriction. As such, GDF11 could be considered as an important therapeutic candidate for age-related neurodegenerative and metabolic disorders.
Identifiants
pubmed: 31637864
doi: 10.1111/acel.13038
pmc: PMC6974718
doi:
Substances chimiques
Adiponectin
0
Bone Morphogenetic Proteins
0
Gdf11 protein, mouse
0
Growth Differentiation Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13038Subventions
Organisme : Agence Nationale de Recherche
ID : ANR-10-LABX-73
Pays : International
Organisme : Agence Nationale de Recherche
ID : ANR-11-IDEX-0004-02
Pays : International
Organisme : Agence Nationale de Recherche
ID : ANR-15-CE37-0004-01
Pays : International
Organisme : Morrison Trust Foundation
Pays : International
Organisme : Barshop Institute Nathan Shock Center
Pays : International
Informations de copyright
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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