Unfolded protein response in myelin disorders.
ER
Schwann cell
UPR
axon
multiples sclerosis
myelin
oligodendrocyte
spinal cord injury
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
23
10
2019
pubmed:
23
10
2019
medline:
23
10
2019
Statut:
ppublish
Résumé
Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions. Nevertheless, persistent, unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells. Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin, including multiples sclerosis, Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher disease, vanishing white matter disease, spinal cord injury, tuberous sclerosis complex, and hypoxia-induced perinatal white matter injury. In this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders.
Identifiants
pubmed: 31638085
pii: NeuralRegenRes_2020_15_4_636_266903
doi: 10.4103/1673-5374.266903
pmc: PMC6975143
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
636-645Subventions
Organisme : NINDS NIH HHS
ID : R01 NS094151
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105689
Pays : United States
Déclaration de conflit d'intérêts
None
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