On-Demand Electrochemical Epoxidation in Nano-Electrospray Ionization Mass Spectrometry to Locate Carbon-Carbon Double Bonds.

double bonds electrochemistry isomers lipids mass spectrometry

Journal

Angewandte Chemie (International ed. in English)

ISSN: 1521-3773

Titre abrégé: Angew Chem Int Ed Engl

Pays: Germany

ID NLM: 0370543

Informations de publication

Date de publication:
02 01 2020

Historique:

received: 29 08 2019

revised: 03 10 2019

pubmed: 23 10 2019

medline: 23 10 2019

entrez: 23 10 2019

Statut: ppublish

Résumé

Reported here is the first on-demand electrochemical epoxidation incorporated into the standard nano-electrospray ionization mass spectrometry (nanoESI-MS) workflow for double-bond identification. The capability lies in a novel tunable electro-epoxidation of double bonds, where onset of the reaction can be controlled by simply tuning the spray voltage. On-demand formation of mono-/multiple epoxides is achieved at different voltages. The electro-epoxidized products are then fragmented by tandem MS to generate diagnostic ions, indicating the double bond position(s). The process is completed within seconds, holding great potential for high-throughput analysis. The rapid switch-on/off electro-epoxidation of a single sample, the low sample consumption, the demonstrated applicability to complex lipids containing multiple double bonds, and the advantage of not requiring extra apparatus make this method attractive for use in lipid-related biological studies.

Identifiants

DOI: 10.1002/anie.201911070 PMID: 31639243

pubmed: 31639243

doi: 10.1002/anie.201911070

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

209-214

Subventions

Organisme : Texas A and M University-Central Texas

ID : Start-up funds

Pays : International

Informations de copyright

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