Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer's Disease:

Alzheimer Disease / drug therapy Animals Blood-Brain Barrier / drug effects Cell Line, Tumor Drug Delivery Systems / methods Humans Indoles / administration & dosage Male Maze Learning / drug effects Mice Mice, Inbred ICR Protein Structure, Secondary
Alzheimer’s disease acetylcholinesterase fascaplysin neuroinflammation oxidative stress β-amyloid

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
20 11 2019
Historique:
pubmed: 23 10 2019
medline: 26 9 2020
entrez: 23 10 2019
Statut: ppublish

Résumé

Alzheimer's disease (AD) is characterized by progressive neurodegeneration and impaired cognitive functions. Fascaplysin is a β-carboline alkaloid isolated from marine sponge

Identifiants

DOI: 10.1021/acschemneuro.9b00503 PMID: 31639294
pubmed: 31639294
doi: 10.1021/acschemneuro.9b00503
doi:

Substances chimiques

Indoles 0
fascaplysine 114719-57-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4741-4756

Auteurs

Hanbo Pan (H)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.

Hongda Qiu (H)

School of Materials Science and Chemical Engineering , Ningbo University , Ningbo 315211 , China.

Ke Zhang (K)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.

Panpan Zhang (P)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.

Weida Liang (W)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.

Mengxiang Yang (M)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.

Chenye Mou (C)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.

Miaoman Lin (M)

School of Materials Science and Chemical Engineering , Ningbo University , Ningbo 315211 , China.

Ming He (M)

School of Materials Science and Chemical Engineering , Ningbo University , Ningbo 315211 , China.

Xiao Xiao (X)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.

Difan Zhang (D)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.

Haixing Wang (H)

Zhejiang Province Key Laboratory of Anesthesiology, Department of Anesthesiology , The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , Wenzhou 325000 , China.

Fufeng Liu (F)

State Key Laboratory of Food Nutrition and Safety, College of Biotechnology , Tianjin University of Science & Technology , Tianjin 300457 , China.

Yongmei Li (Y)

School of Materials Science and Chemical Engineering , Ningbo University , Ningbo 315211 , China.

Haixiao Jin (H)

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences , Ningbo University , Ningbo 315800 , China.

Xiaojun Yan (X)

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences , Ningbo University , Ningbo 315800 , China.

Hongze Liang (H)

School of Materials Science and Chemical Engineering , Ningbo University , Ningbo 315211 , China.

Wei Cui (W)

Ningbo Key Laboratory of Behavior Neuroscience, Zhejiang Province Key Laboratory of Pathophysiology, School of Medicine , Ningbo University , Ningbo 315211 , China.
State Key Laboratory of Food Nutrition and Safety, College of Biotechnology , Tianjin University of Science & Technology , Tianjin 300457 , China.
ORCID: 0000-0002-8645-4278

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Eucaryotes › Animaux › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage du labyrinthe › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée ICR › Fascaplysin Derivatives Are Potent Multitarget...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Fascaplysin Derivatives Are Potent Multitarget...