Is there today a place for corticosteroids in the treatment of scleroderma?

Adrenal Cortex Hormones / adverse effects Humans Kidney Diseases / etiology Scleroderma, Systemic / complications
Corticosteroids Efficacy Risk Systemic sclerosis

Journal

Autoimmunity reviews
ISSN: 1873-0183
Titre abrégé: Autoimmun Rev
Pays: Netherlands
ID NLM: 101128967

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 08 07 2019
accepted: 11 07 2019
pubmed: 23 10 2019
medline: 6 2 2020
entrez: 23 10 2019
Statut: ppublish

Résumé

In systemic sclerosis (SSc), the use of corticosteroids (CS) is controversial due to their association with scleroderma renal crisis (SRC). However, patients with very early and early disease, characterised by main inflammatory component, may benefit from CS therapy. The aim of this review is to discuss pros and cons of CS treatment in SSc, providing current evidence about the use of CS in SSc. Moreover, we discuss also the underlying pathogenetic mechanisms that may be the background for the potential harms and efficacy of CS in SSc.

Identifiants

DOI: 10.1016/j.autrev.2019.102403 PMID: 31639515
pubmed: 31639515
pii: S1568-9972(19)30210-1
doi: 10.1016/j.autrev.2019.102403
pii:
doi:

Substances chimiques

Adrenal Cortex Hormones 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102403

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Jelena Blagojevic (J)

Department of Experimental and Clinical Medicine, University of Florence and Division of Rheumatology AOUC, Florence, Italy. Electronic address: jelena308@hotmail.com.

Paul Legendre (P)

Service de Médecine Interne, Hôpital Cochin, Centre de Référence National pour les Maladies Systémiques Autoimmunes Rares, DHU Authors, Assistance Publique-Hôpitaux de Paris, Paris, France.

Marco Matucci-Cerinic (M)

Department of Experimental and Clinical Medicine, University of Florence and Division of Rheumatology AOUC, Florence, Italy.

Luc Mouthon (L)

Service de Médecine Interne, Hôpital Cochin, Centre de Référence National pour les Maladies Systémiques Autoimmunes Rares, DHU Authors, Assistance Publique-Hôpitaux de Paris, Paris, France; Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, France.

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Classifications MeSH

questionsmedicales.fr › Hormones corticosurrénaliennes › Is there today a place for corticosteroids in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Is there today a place for corticosteroids in...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Is there today a place for corticosteroids in...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Sclérodermie systémique › Is there today a place for corticosteroids in...