Analytical Differences in Intraoperative Parathyroid Hormone Assays.
Journal
The journal of applied laboratory medicine
ISSN: 2576-9456
Titre abrégé: J Appl Lab Med
Pays: England
ID NLM: 101693884
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
10
04
2018
accepted:
07
12
2018
entrez:
23
10
2019
pubmed:
23
10
2019
medline:
18
9
2020
Statut:
ppublish
Résumé
We compared the rates of intraoperative parathyroid hormone (PTH) decline using the Siemens Immulite Serial blood samples from 95 patients undergoing parathyroidectomy were collected and measured using the 2 immunoassays. Specimens from the first 15 patients were measured simultaneously in the OR and CCL and used for the TAT study. In addition to 2 baseline samples, specimens were collected at 5, 10, and 15 min (for some patients, >15 min) after parathyroidectomy. In the TAT study, a significant difference was observed (OR median 20 min vs CCL median 27 min; There was a slightly longer TAT in the CCL compared with running the assay directly within the OR (median difference of approximately 7 min). For a majority of the patients, both methods showed equivalent rates of PTH decline; however, for approximately 20% of the patients, there was a slower rate of PTH decline using the Roche assay.
Sections du résumé
BACKGROUND
We compared the rates of intraoperative parathyroid hormone (PTH) decline using the Siemens Immulite
METHODS
Serial blood samples from 95 patients undergoing parathyroidectomy were collected and measured using the 2 immunoassays. Specimens from the first 15 patients were measured simultaneously in the OR and CCL and used for the TAT study. In addition to 2 baseline samples, specimens were collected at 5, 10, and 15 min (for some patients, >15 min) after parathyroidectomy.
RESULTS
In the TAT study, a significant difference was observed (OR median 20 min vs CCL median 27 min;
CONCLUSIONS
There was a slightly longer TAT in the CCL compared with running the assay directly within the OR (median difference of approximately 7 min). For a majority of the patients, both methods showed equivalent rates of PTH decline; however, for approximately 20% of the patients, there was a slower rate of PTH decline using the Roche assay.
Identifiants
pubmed: 31639754
pii: jalm.2018.026815
doi: 10.1373/jalm.2018.026815
doi:
Substances chimiques
Parathyroid Hormone
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
788-798Informations de copyright
© 2018 American Association for Clinical Chemistry.