PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites.
biocompatibility
composite films
mechanical properties
nanocrystalline cellulose
polyester materials
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
21 Oct 2019
21 Oct 2019
Historique:
received:
02
10
2019
revised:
17
10
2019
accepted:
18
10
2019
entrez:
24
10
2019
pubmed:
24
10
2019
medline:
24
10
2019
Statut:
epublish
Résumé
The development of biocompatible composite materials is in high demand in many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series of poly (D,L-lactide) and poly (ε-caprolactone)-based films filled with neat and modified with poly (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis of scanning electron and atomic force microscopies' results shows that the modification of NCC with poly (glutamic acid) favored the better distribution of the nanofiller in the polymer matrix. Investigating the ability of the developed materials to attract and retain calcium ions led to the conclusion that composites containing NCC modified with PGlu induced better mineralization from model solutions than composites containing neat NCC. Moreover, compared to unmodified NCC, functionalization with PGlu improved the mechanical properties of composite films. The subcutaneous implantation of these composite materials into the backs of rats and the further histological investigation of neighboring tissues revealed the better biocompatibility of polyester materials filled with NCC-PGlu.
Identifiants
pubmed: 31640122
pii: ma12203435
doi: 10.3390/ma12203435
pmc: PMC6829302
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Ministry of Education and Science
ID : 14.W03.31.0014
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