A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila.
Animals
Animals, Genetically Modified
Drosophila
/ embryology
Drosophila Proteins
/ genetics
Embryo, Nonmammalian
/ physiology
Gene Expression Regulation
Gene Silencing
Interneurons
/ physiology
Larva
/ physiology
Locomotion
/ physiology
Maf Transcription Factors, Large
/ genetics
Motor Activity
/ physiology
Proto-Oncogene Proteins
/ genetics
Spinal Nerve Roots
/ physiology
gamma-Aminobutyric Acid
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
22 10 2019
22 10 2019
Historique:
received:
30
11
2018
accepted:
23
09
2019
entrez:
24
10
2019
pubmed:
24
10
2019
medline:
17
1
2020
Statut:
epublish
Résumé
Interneurons (INs) coordinate motoneuron activity to generate appropriate patterns of muscle contractions, providing animals with the ability to adjust their body posture and to move over a range of speeds. In Drosophila larvae several IN subtypes have been morphologically described and their function well documented. However, the general lack of molecular characterization of those INs prevents the identification of evolutionary counterparts in other animals, limiting our understanding of the principles underlying neuronal circuit organization and function. Here we characterize a restricted subset of neurons in the nerve cord expressing the Maf transcription factor Traffic Jam (TJ). We found that TJ
Identifiants
pubmed: 31641138
doi: 10.1038/s41467-019-12693-6
pii: 10.1038/s41467-019-12693-6
pmc: PMC6805931
doi:
Substances chimiques
Drosophila Proteins
0
Maf Transcription Factors, Large
0
Proto-Oncogene Proteins
0
tj protein, Drosophila
0
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4796Références
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