Clinical characteristics and molecular epidemiology of children with meningitis in Tehran, Iran: a prospective study.
Children
diagnosis
genotype
meningitis
molecular epidemiology
Journal
New microbes and new infections
ISSN: 2052-2975
Titre abrégé: New Microbes New Infect
Pays: England
ID NLM: 101624750
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
08
03
2019
revised:
18
07
2019
accepted:
20
08
2019
entrez:
24
10
2019
pubmed:
24
10
2019
medline:
24
10
2019
Statut:
epublish
Résumé
The molecular epidemiology of meningitis in children is unclear in Iran, and data are scarce. We aimed to characterize its clinical and paraclinical features as well as to determine the distribution of genotype/capsular types of common bacterial meningitis agents in children in Iran. All children suspected to have meningitis aged 4 days to 15 years were enrolled onto a prospective cross-sectional study from January 2015 to September 2017. Diagnostic values of clinical features, cerebrospinal fluid and serum parameters were evaluated independently and in combination with each other by multivariate logistic regression to develop a diagnostic rule. Genotype/capsular types of all the isolates were determined by targeting serotype-specific genes with uniplex or multiplex PCR. Among 119 patients suspected of having meningitis, 43 had bacterial meningitis, 19 aseptic and one tuberculous; and there were 56 nonmeningitis cases (NMC). Presentation of four features at the same time-cerebrospinal fluid white blood cell count, protein, polymorphonuclear leukocytes and serum C-reactive protein-revealed 100% sensitivity and 86.4% specificity for diagnosis of bacterial meningitis.
Identifiants
pubmed: 31641511
doi: 10.1016/j.nmni.2019.100594
pii: S2052-2975(19)30091-5
pii: 100594
pmc: PMC6796727
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100594Informations de copyright
© 2019 Published by Elsevier Ltd.
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