The use of microindentation for the study of bone properties in type 1 diabetes mellitus patients.
Chronic complications
Fracture risk assessment
Microindentation
Osteoporosis
Type 1 diabetes mellitus
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
ISSN: 1433-2965
Titre abrégé: Osteoporos Int
Pays: England
ID NLM: 9100105
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
23
05
2019
accepted:
24
09
2019
pubmed:
24
10
2019
medline:
5
2
2021
entrez:
24
10
2019
Statut:
ppublish
Résumé
Diabetes mellitus is associated with a higher risk of fracture. In this study, we analysed the bone quality of premenopausal women with type 1 diabetes mellitus by microindentation. No differences in bone quality were identified between patients and healthy controls, suggesting that intensive insulin therapy can preserve bone health. To compare the bone quality of women with type 1 diabetes mellitus (T1DM) and healthy controls, and to determine the relationship with bone mineral density (BMD). This was a cross-sectional study of 45 premenopausal women with T1DM and 21 healthy controls, matched according to age and BMI. Clinical parameters, BMD and bone tissue mechanical properties (assessed using the bone material strength index [BMSi]) were evaluated in each group using microindentation. In T1DM patients, glycosylated haemoglobin (HbA No differences in BMSi or BMD between T1DM patients and healthy controls were identified. In the T1DM patients, the mean HbA T1DM premenopausal patients showed bone tissue properties comparable to those shown by controls. Further larger-scale studies should be conducted to confirm these results.
Identifiants
pubmed: 31641800
doi: 10.1007/s00198-019-05178-1
pii: 10.1007/s00198-019-05178-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-180Références
Diabetes. 2000 Apr;49(4):626-32
pubmed: 10871201
Rev Esp Cardiol. 2010 Apr;63(4):423-9
pubmed: 20334808
Crit Pathw Cardiol. 2005 Dec;4(4):198-203
pubmed: 18340209
Diabetes Care. 2006 Jul;29(7):1573-8
pubmed: 16801581
J Pediatr. 2004 Jan;144(1):56-62
pubmed: 14722519
J Bone Miner Res. 2007 Sep;22(9):1317-28
pubmed: 17501667
J Clin Endocrinol Metab. 2012 Apr;97(4):1277-84
pubmed: 22337915
J Bone Miner Res. 2017 May;32(5):1062-1071
pubmed: 27943408
J Bone Miner Res. 2014 Apr;29(4):787-95
pubmed: 24123088
J Trauma. 2002 Apr;52(4):660-6
pubmed: 11956379
Curr Osteoporos Rep. 2016 Dec;14(6):327-336
pubmed: 27744554
Am J Epidemiol. 2007 Sep 1;166(5):495-505
pubmed: 17575306
N Engl J Med. 1993 Sep 30;329(14):977-86
pubmed: 8366922
Bone Rep. 2016 Dec;5:181-185
pubmed: 27975078
J Bone Miner Res. 2010 Aug;25(8):1877-85
pubmed: 20200991
Diabetes Care. 2014 Jan;37 Suppl 1:S14-80
pubmed: 24357209
Osteoporos Int. 2005 Dec;16(12):1506-12
pubmed: 15824889
Osteoporos Int. 2007 Apr;18(4):427-44
pubmed: 17068657
J Clin Endocrinol Metab. 2018 Sep 1;103(9):3531-3539
pubmed: 30032248