Suicidal ideation is common in autosomal dominant Alzheimer's disease at-risk persons.
autosomal dominant Alzheimer's disease
dominantly inherited Alzheimer' network
neuropsychiatric symptoms
suicidal ideation
Journal
International journal of geriatric psychiatry
ISSN: 1099-1166
Titre abrégé: Int J Geriatr Psychiatry
Pays: England
ID NLM: 8710629
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
06
03
2019
accepted:
15
09
2019
pubmed:
24
10
2019
medline:
12
11
2020
entrez:
24
10
2019
Statut:
ppublish
Résumé
To study the frequency of suicidal ideation and its association with clinical and neurobiological correlates among cognitively intact autosomal dominant Alzheimer's disease (ADAD) at-risk individuals. In a cross-sectional study of 183 ADAD at-risk individuals (91 mutation carriers and 92 noncarriers), we compared the frequency of suicidal ideation among carriers and noncarriers. Linear mixed-effects models with family-level random effects evaluated the relationships between geriatric depression scale (GDS), neuropsychiatric inventory-questionnaire (NPI-Q), and suicidal ideation scores among all ADAD at-risk individuals. An interaction term was added to the regression models to evaluate the interactions of suicidal ideation and mutation status on neuropsychiatric symptoms. Twenty-six (14.20%) ADAD at-risk individuals (13 [14.28%] carriers and 13 [14.13%] noncarriers) had suicidal ideation. The frequency of suicidal ideation did not differ between carriers and noncarriers. Suicidal ideation was associated with higher GDS among all ADAD at-risk individuals. When stratified into mutation carrier status, noncarriers with suicidal ideation had higher GDS than carriers. There was no statistically significant association between suicidal ideation and NPI-Q among ADAD at-risk individuals. Awareness of mutation status, neuropsychological performances, and cerebrospinal fluid AD biomarkers were not associated with suicidal ideation among carriers and noncarriers. Suicidal ideation is common among cognitively intact ADAD at-risk individuals. While ADAD at-risk individuals with suicidal ideation have greater depressive symptoms, noncarriers with suicidal ideation have higher GDS scores than carriers. Interestingly, awareness of the mutation status was not associated with suicidal ideation in our study. Early identification of suicidal thoughts can facilitate timely interventions to prevent suicidal behaviours. Keywords autosomal dominant Alzheimer's diseasedominantly inherited Alzheimer's networkneuropsychiatric symptomssuicidal ideation.
Identifiants
pubmed: 31642105
doi: 10.1002/gps.5215
pmc: PMC7232741
mid: NIHMS1588014
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
60-68Subventions
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2019 John Wiley & Sons, Ltd.
Références
Sociol Health Illn. 2006 Nov;28(7):969-88
pubmed: 17163862
J Affect Disord. 2016 Jan 15;190:128-136
pubmed: 26496018
Alzheimers Res Ther. 2015 Jul 22;7(1):50
pubmed: 26203303
Int J Psychiatry Med. 2015;49(4):296-308
pubmed: 26060259
J Huntingtons Dis. 2016 May 31;5(2):185-98
pubmed: 27258585
Sci Transl Med. 2014 Mar 5;6(226):226ra30
pubmed: 24598588
Arch Gen Psychiatry. 1999 Jul;56(7):617-26
pubmed: 10401507
Mol Genet Metab. 2011 Apr;102(4):494-504
pubmed: 21220204
Neurosci Biobehav Rev. 2017 Jan;72:10-27
pubmed: 27836463
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Alzheimers Dement. 2011 Nov;7(6):567-73
pubmed: 22055973
World J Biol Psychiatry. 2011 Aug;12(5):319-39
pubmed: 21385016
Am J Hum Genet. 1999 May;64(5):1289-92
pubmed: 10205259
Transl Psychiatry. 2018 Jan 22;8(1):22
pubmed: 29353878
Am J Hum Genet. 1999 May;64(5):1293-304
pubmed: 10205260
J Clin Psychiatry. 2017 Jun;78(6):e614-e621
pubmed: 28199073
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Br J Psychiatry. 2008 Feb;192(2):98-105
pubmed: 18245022
Am J Psychiatry. 2011 Dec;168(12):1266-77
pubmed: 22193671
Life Sci. 1983 Dec 26;33(26):2609-14
pubmed: 6198573
Int J Geriatr Psychiatry. 2015 Mar;30(3):274-83
pubmed: 24816626
J Affect Disord. 2013 Oct;151(1):248-58
pubmed: 23876196
Alzheimers Res Ther. 2011 Jan 06;3(1):1
pubmed: 21211070
Alzheimers Res Ther. 2013 Oct 17;5(5):48
pubmed: 24131566
Arch Gen Psychiatry. 2002 Sep;59(9):801-7
pubmed: 12215079
J Neurol Neurosurg Psychiatry. 2004 Mar;75(3):500-2
pubmed: 14966176
J Consult Clin Psychol. 2000 Jun;68(3):371-7
pubmed: 10883553
Lancet Psychiatry. 2014 Jun;1(1):63-72
pubmed: 26360403
Arch Suicide Res. 2008;12(2):93-110
pubmed: 18340592
Neuropsychology. 2014 Jan;28(1):19-29
pubmed: 24219606
Trends Neurosci. 2012 Jan;35(1):14-23
pubmed: 22177979
Am J Psychiatry. 2005 Apr;162(4):725-31
pubmed: 15800145
JAMA. 2005 Oct 26;294(16):2064-74
pubmed: 16249421
Am J Med Genet C Semin Med Genet. 2005 Feb 15;133C(1):25-33
pubmed: 15645480
J Geriatr Psychiatry Neurol. 1991 Jul-Sep;4(3):173-8
pubmed: 1953971
Age Ageing. 1998 Jul;27(4):503-7
pubmed: 9884008
Psychol Med. 2014 Jun;44(8):1663-73
pubmed: 24016405
Eur Neuropsychopharmacol. 2013 Oct;23(10):1280-7
pubmed: 23453639
J Neuropsychiatry Clin Neurosci. 2000 Spring;12(2):233-9
pubmed: 11001602
Brain. 2015 Apr;138(Pt 4):1036-45
pubmed: 25688083