Insulin resistance and intestinal integrity in children with and without HIV infection in Uganda.
HIV-exposed uninfected
gut integrity
immune activation
inflammation
insulin resistance
Journal
HIV medicine
ISSN: 1468-1293
Titre abrégé: HIV Med
Pays: England
ID NLM: 100897392
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
06
06
2019
revised:
22
08
2019
accepted:
03
09
2019
pubmed:
24
10
2019
medline:
2
6
2021
entrez:
24
10
2019
Statut:
ppublish
Résumé
The risk of cardiometabolic complications in children with perinatally acquired HIV infection (PHIVs) and in perinatally HIV-exposed but uninfected children (HEUs) and its relationship to systemic inflammation and markers of gut integrity are not well established. In this current study, we assed insulin resitance in PHIV compared to HEUs and HIV unexposed uninfected children and explored potential association with intestinal damage biomarkers. This was a cross-sectional study in PHIVs, HEUs and HIV-unexposed, uninfected children (HUUs) aged 2-10 years enrolled in Uganda. PHIVs were on stable antiretroviral therapy (ART) with HIV viral load < 400 HIV-1 RNA copies/mL. Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). We measured markers of systemic inflammation, monocyte activation and gut integrity. Kruskal-Wallis tests were used to compare markers by HIV status; Pearson correlation and multiple linear regressions were used to assess associations of the HOMA-IR index with biomarkers of intestinal damage and translocation. Overall, 172 participants were enrolled in the study (57 PHIVs, 59 HEUs and 56 HUUs). The median age was 7.8 [interquartile range (IQR) 6.39, 8.84] years, 55% were female and the median body mass index (BMI) was 15 (IQR 14.3, 15.8) kg/m Despite viral suppression, Ugandan PHIVs have disturbances in glucose metabolism. Higher BMI, and not immune activation or alteration of gut integrity, was associated with insulin resistance in this population.
Identifiants
pubmed: 31642582
doi: 10.1111/hiv.12808
pmc: PMC6980894
mid: NIHMS1051689
doi:
Substances chimiques
Cholesterol, HDL
0
Triglycerides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-127Subventions
Organisme : NICHD NIH HHS
ID : K23 HD088295
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK118757
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : K23HD088295-01A1
Pays : International
Informations de copyright
© 2019 British HIV Association.
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