Identification of Opioids and Related Substances using Handheld Raman Spectrometers.
FDA
fentanyl
field testing
forensic science
handheld Raman
opioids
Journal
Journal of forensic sciences
ISSN: 1556-4029
Titre abrégé: J Forensic Sci
Pays: United States
ID NLM: 0375370
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
01
08
2019
revised:
10
09
2019
accepted:
30
09
2019
pubmed:
24
10
2019
medline:
12
3
2020
entrez:
24
10
2019
Statut:
ppublish
Résumé
This study describes the performance of handheld Raman devices for detecting one hundred opioids and related substances including fentanyl and several analogs. Using a single "parent" device, signatures (spectra) with excellent signal-to-noise ratios were generated using <5 mg of most compounds. The signatures were added to a method (library), which was electronically transferred to three "daughter" devices. The devices were able to discriminate different salt forms and isomers. On average, the daughter devices yielded a true-positive rate of 97.3% for generating an alarm for opioids and were 93.3% effective for correctly identifying the opioid. The devices yielded true-negative, false-positive and false-negative rates of 100%, 0%, and 2.7%, respectively, where false negatives were due to weak signal and fluorescence. These data demonstrate that the parent-daughter electronic transfer method was successful and effective, which permits the ability to develop methods in the laboratory that can be seamlessly pushed out to field devices.
Identifiants
pubmed: 31643087
doi: 10.1111/1556-4029.14217
doi:
Substances chimiques
Analgesics, Opioid
0
Fentanyl
UF599785JZ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
421-427Informations de copyright
Published 2019. This article is a U.S. Government work and is in the public domain in the USA.
Références
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