T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis.
T cell receptor α and β pairing
human
immune phenotyping
immune tolerance
immunosequencing
multiple sclerosis
pregnancy
repertoire sequencing
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
22 10 2019
22 10 2019
Historique:
received:
31
05
2018
revised:
10
07
2019
accepted:
06
09
2019
entrez:
24
10
2019
pubmed:
24
10
2019
medline:
17
9
2020
Statut:
ppublish
Résumé
Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research paradigm to explore dynamics of immune repertoire changes during active and inactive disease. Here, we characterize immunomodulation at the single-clone level by sequencing the T cell repertoire in healthy women and female MS patients over the course of pregnancy. Clonality is significantly reduced from the first to third trimester in MS patients, indicating that the T cell repertoire becomes less dominated by expanded clones. However, only a few T cell clones are substantially modulated during pregnancy in each patient. Moreover, relapse-associated T cell clones identified in an individual patient contract during pregnancy and expand during a postpartum relapse. Our data provide evidence that profiling the T cell repertoire during pregnancy could serve as a tool to discover and track "private" T cell clones associated with disease activity in autoimmunity.
Identifiants
pubmed: 31644905
pii: S2211-1247(19)31202-1
doi: 10.1016/j.celrep.2019.09.025
pii:
doi:
Substances chimiques
Biomarkers
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
810-815.e4Subventions
Organisme : Deutsche Forschungsgemeinschaft
Pays : International
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.